Oil-in-water-type compound nitazoxanid nanoemulsion and preparation method thereof

A nanometer, oil-in-water technology of nitazoxanide, applied in the field of medicine, can solve the problems of low bioavailability, slow drug dissolution rate, thermodynamic instability, etc., and achieve improved stability, high thermodynamic stability, well tolerated effect

Inactive Publication Date: 2012-07-04
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tablets are traditional preparations and commonly used preparations, which need to be prepared by adding excipients and compressing. After oral administration, the drug dissolves slowly, has low bioavailability, and has the disadvantage of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] A kind of oil-in-water type compound nitazoxanide nanoemulsion, the quality of each component:

[0059] Polyoxyethylene (40) hydrogenated castor oil 27.0g, absolute ethanol 3.0g, nitazoxanide 0.01g, cinnamaldehyde 7.0g, distilled water 62.99g.

[0060] Above-mentioned each component is made oil-in-water type compound recipe nitazoxanide nanoemulsion, comprises the following steps:

[0061] 1) Accurately weigh polyoxyethylene (40) hydrogenated castor oil, absolute ethanol, nitazoxanide, cinnamaldehyde, and distilled water according to the formula, and set aside;

[0062] 2) Dissolving the amount of nitazoxanide in the amount of cinnamaldehyde, and using the solution as the oil phase;

[0063] 3) Add the amount of polyoxyethylene (40) hydrogenated castor oil and absolute ethanol into the oil phase and stir well;

[0064] 4) Slowly add distilled water dropwise to the mixture in step 3), and stir while adding. During the process of adding water and stirring, the m...

Embodiment 2

[0066] It consists of Tween-80 19.0g, absolute ethanol 3.5g, nitazoxanide 0.15g, cinnamaldehyde 2.0g, distilled water 75.35g.

Embodiment 3

[0068] It consists of 24.0g of polyoxyethylene ether castor oil, 2.0g of absolute ethanol, 0.08g of nitazoxanide, 3.0g of cinnamaldehyde, and 70.92g of distilled water.

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Abstract

The invention discloses an oil-in-water-type compound nitazoxanid nanoemulsion combination, wherein, the particle size of nanoemulsion ranges from 1 to 100 nm, and the oil-in-water-type compound nitazoxanid nanoemulsion combination comprises the following raw materials by mass percent: surface-active agents accounting for 19.0 to 35.0 percent, cosurfactants accounting for 0 to 7.0 percent, nitazoxanid accounting for 0.01 to 0.21 percent, cinnamic aldehyde accounting for 0.1 to 8.0 percent and distilled water that is the rest ingredient; and the sum of the mass percent of the raw materials is 100 percent. The nanoemulsion improves the solvability of nitazoxanid and the medical bioavailability, improves the curative effects of medicines, reduces the medicine dose, has higher activity of resisting protozoa, worms, bacteria, virus and the like, and is used for treating diseases of people or livestocks caused by protozoa, the worms, the bacteria, virus and the like. The oil-in-water-type compound nitazoxanid nanoemulsion combination is safe to use, has the advantages of obvious curative effects, simple preparation method and wide market prospect in medicine field, and is convenient to popularize and apply.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a drug that can be used for human or livestock protozoa (Cryptosporidium parvum, amoeba, etc.), worms (most nematodes, tapeworms and trematodes), bacteria (gram-positive bacteria and An oil-in-water type compound nitazoxanide nanoemulsion for the treatment of diseases caused by infections such as Gram-negative bacteria) and viruses (rotavirus, etc.) and a preparation method thereof. Background technique [0002] Nitazoxin is especially called nitazolamide; o-[N-(5-nitrothiazol-2-yl)carbamoyl]phenol acetate is a derivative of nitrothiasalicylic acid amide. It was first successfully developed by Romark Laboratories in the 1970s, and it was first launched in Mexico in 1996 as an antiparasitic drug. English trade names: Daxon and Colufase, later listed in Australia, New Zealand, the United States and other countries, trade name CryptazTM, listed dosage forms are tablets (500mg) and dry suspens...

Claims

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Application Information

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IPC IPC(8): A61K31/426A61K9/107A61K47/08A61P31/04A61P31/12A61P33/02A61P33/10A61K31/11
Inventor 欧阳五庆郭建军沈巧艳
Owner NORTHWEST A & F UNIV
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