A drug composition and its preparation and use method

Abstract

The invention provides a drug composition and its preparation and use methods. The composition for administration includes solid preparations loaded with effective doses of therapeutic components, absorption promoters, pharmaceutical adjuvants and bioadhesive layers containing bioadhesive polymers, and also includes an optional anti-permeation or semi-permeable coating layer, so that the preparation Therapeutic components and absorption enhancers in have unidirectional release capability. The unidirectional release channel with unidirectional release capability in the preparation is formed by manual or laser ablation process, and the release rate of the therapeutic component and the absorption enhancer from the solid preparation is almost synchronized. The invention also provides the preparation and use methods of the administration composition. The low-dose solid dosage form prepared by the non-solvent granulation process can maintain the uniformity and stability of the therapeutic components. The administration composition of the invention can promote the absorption of poorly absorbed drugs, improve bioavailability, adjust pharmacokinetic characteristics, and improve drug absorption efficiency, and the preparation is cheap and relatively easy to produce.

Description

technical field [0001] The invention mainly relates to the field of drug delivery, and is especially suitable for pharmaceutical components with poor absorption and low bioavailability in traditional administration, so as to improve the absorption and bioavailability of therapeutic drugs. In particular, the invention relates to drug delivery compositions and methods for their preparation and use. Background technique [0002] Oral administration is the most common and most acceptable way of administration. But for many drugs, the absorption efficiency of oral administration is not good. For example, biologically active macromolecules such as proteins, polypeptides, polysaccharides, and nucleic acids cannot usually be administered orally due to factors such as enzymatic degradation, poor absorption, or instability. Similarly, many small molecule drugs, such as cyclosporine A, fenofibrate, statin lipid-lowering drugs, sartan antihypertensive drugs, antibiotics such as ceftri...

AI Technical Summary

Problems solved by technology

However, the addition of such high doses of absorption enhancers in oral formulations often leads to toxic reactions and safety concerns

[0007] So far, there is no safe and effective solution for those oral drugs that are difficult to absorb and have low bioavailability, especially macromolecular drugs

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