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Medicinal composition capable of expanding tracheal smooth muscles and application thereof

A technology of tracheal smooth muscle and composition, which is applied in the field of drugs and applications that can expand tracheal smooth muscle, can solve the problems of ineffective expansion of tracheal smooth muscle, and achieve excellent drug efficacy, low cost, and low price

Inactive Publication Date: 2012-07-18
LOGISTICS UNIV OF CAPF
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the prescription still does not effectively dilate the tracheal smooth muscle

Method used

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  • Medicinal composition capable of expanding tracheal smooth muscles and application thereof
  • Medicinal composition capable of expanding tracheal smooth muscles and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0026] The composition formula of table 1 different proportions

[0027] Matrine 99% pure

Glycyrrhizic Acid 99% Pure

Baicalin 50% pure

Example 1

1

2.5

5

Example 2

2.5

5

1

Example 3

5

1

2.5

[0028] The composition formula of table 2 different proportions

[0029] Matrine 75% Purity

Glycyrrhizic Acid 75% Purity

Baicalin 75% purity

Example 4

5

1

2.5

Example 5

1

1

2

Example 6

5

2.5

1

[0030] The composition formula of table 3 different proportions

[0031] Matrine 50% Purity

Glycyrrhizic Acid 50% Purity

Baicalin 99% pure

Example 7

1

1

1

Example 8

2.5

5

1

Example 9

5

2.5

1

Example 10

2

1

2

[0032] 2. In vivo anti-asthma test

[0033] 2.1 Composition of E...

Embodiment 1-10

[0042] 120 guinea pigs were taken as qualified guinea pigs after the test, half male and half male, and the male and female were separated into cages under the same conditions for adaptive feeding for 1 week, and routine feeding. Then they were randomly divided into 12 groups, 10 in each group, half male and half male. The guinea pigs in each group were administered with Examples 1-10 (100 mg / kg in terms of composition), physiological saline 5 ml / kg by intragastric administration, and aminophylline 100 mg / kg by intramuscular injection. After 1 hour, the guinea pigs were put into the same glass bell jar (one at a time), and sprayed with an isovolumic mixture of 0.1% histamine phosphate and 2% acetylcholine at constant pressure for 8 seconds. Observe the latent period of wheezing induced by guinea pigs (from the beginning of spraying to convulsions and falling to the ground). Those who do not fall over 360s will be counted as 360s. The results are shown in Table 5.

[0043] T...

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PUM

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Abstract

The invention discloses a medicinal composition capable of expanding tracheal smooth muscles and an application thereof. The medicinal composition consists of the following raw materials in parts by weight: 1-5 parts of glycyrrhizin, 1-5 parts of baicalin and 1-5 parts of sophocarpidine. In the composition, an extract is refined into an effective part, so that the dosage is reduced, tracheal smooth muscles can be expanded, a more superior medicinal effect is achieved, and adverse reactions existing in a prescription of the prior art are reduced; and all used raw materials are nontoxic, and have low prices and low costs.

Description

technical field [0001] The invention relates to a medicine combination group, in particular to a medicine capable of dilating trachea smooth muscle and its application. Background technique [0002] Asthma is a common disease, frequently-occurring disease. Morbidity and mortality are increasing year by year worldwide, and it has become one of the major chronic diseases that seriously threaten public health and quality of life. In the past ten years, the prevalence and mortality of asthma in the United States, the United Kingdom, Australia, New Zealand and other countries have been on the rise. There are about 100 million asthma patients in the world, and it has become a major chronic disease that seriously threatens public health. In my country, asthma The prevalence rate of asthma is about 1%, and children can reach 3%. It is estimated that there are more than 10 million asthma patients in the whole country. In recent years, due to the establishment of the theory of airway...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K31/4375A61K31/352A61P11/06
Inventor 陈虹邹忠梅高颖王火曹波白淑芳李覃丁刚张宏武
Owner LOGISTICS UNIV OF CAPF
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