Method for building spleen-deficiency chronic atrophic gastritis gastric precancerous lesions animal model
A technology of atrophic gastritis and gastric precancerous lesions, applied in the establishment of animal models of gastritis and gastric precancerous lesions, and in the field of establishment of animal models of chronic atrophic gastritis with gastric precancerous lesions due to spleen deficiency, achieving reproducible and stable results
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Embodiment 1
[0020] Example 1 Prepare MNNG with sterilized tap water to make a storage solution with a concentration of 10 mg / L, store it in a dark place and refrigerate it, make it into a drinking solution at 80 μg / mL, put it into a 200-mL drinking bottle instead of drinking water (with black light-proof paper on the outside, and The whole preparation process was protected from light), and the rats were allowed to drink freely; after the 5th week of free drinking of the MNNG solution, fasting was started every other day, that is, no fasting on one day, fasting on the next day (no water), and no fasting on the next day , so repeatedly; after the MNNG solution was free to drink, in the 7th week, Xiaochengqi Decoction was added to the gavage of 1ml / monkey / d, 1 time / d, and the modeling was continued for 12 weeks.
Embodiment 2
[0021] Example 2 The prepared 10 mg / L concentration of MNNG storage solution was made into 150 μg / mL drinking solution, and put into a 200mL drinking water bottle instead of drinking water (black light-proof paper was attached to the outside, and the whole preparation process was protected from light). The rats were free to drink; after the 5th week of free drinking of the MNNG solution, fasting was started every other day, that is, no fasting on one day, fasting on the next day (no water), and no fasting on the next day, and so on; after free drinking of the MNNG solution In the 7th week, 2ml of Xiaochengqi decoction was added to the rats by gavage, once a day, and the model was established continuously for 12 weeks.
Embodiment 3
[0022] Example 3 The prepared 10 mg / L concentration of MNNG storage solution was made into 200 μg / mL drinking solution, and put into a 200mL drinking bottle instead of drinking water (black light-proof paper was attached to the outside, and the whole preparation process was protected from light). The rats were free to drink; after the 5th week of free drinking of the MNNG solution, fasting was started every other day, that is, no fasting on one day, fasting on the next day (no water), and no fasting on the next day, and so on; after free drinking of the MNNG solution In the 7th week, 3ml of Xiaochengqi decoction was added to the rats by gavage, once a day, and the model was established continuously for 12 weeks.
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