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External medicinal formula mainly used for treating ichthyosis and xerodermia and process thereof

A technology for xerosis and ichthyosis, which is applied in the field of external medicine for treating ichthyosis and skin xerosis, and can solve the problems of poor drug efficacy stability, affecting therapeutic effect, decomposition, etc.

Active Publication Date: 2013-11-20
福建太平洋制药有限公司
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment methods mainly use lactic acid salt as the main ingredient to make lotions, the curative effect is not long-lasting, and the medicine is easy to lose; some creams with urea as the main medicine are oil-in-water type, the drug effect stability is not good, and they are easy to be affected. The decomposition of temperature and light affects the therapeutic effect

Method used

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  • External medicinal formula mainly used for treating ichthyosis and xerodermia and process thereof
  • External medicinal formula mainly used for treating ichthyosis and xerodermia and process thereof
  • External medicinal formula mainly used for treating ichthyosis and xerodermia and process thereof

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Embodiment Construction

[0015] 150g of urea, 120g of α-hydroxypropionic acid, 30g of glyceryl mono and distearate, 75g of concentrated ammonia solution, 10g of polyoxyl stearate (40), 30g of cholesterol, 90g of glycerin, 180g of white petrolatum, light liquid Add 180g of paraffin, 20g of stearyl alcohol, and purified water to 1000g.

[0016] 1. Preparation of main ingredient: take 120g of a-hydroxypropionic acid and 75g of concentrated ammonia solution, slowly add the concentrated ammonia solution into a-hydroxypropionic acid and keep stirring to make the acid-base neutralization reaction complete (stop stirring, statically After leaving it for 20 minutes, no bubbles will be produced), use pH test paper to detect that the pH of the solution is 4.0 to 6.0, then add 150 g of urea and stir until it dissolves.

[0017] 2. Preparation of the oil phase: Weigh 30g of cholesterol, 20g of stearyl alcohol, 180g of white petrolatum, 30g of mono / distearic acid glyceride, 180g of light liquid paraffin, and 10g of...

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Abstract

The invention relates to an external medicinal formula mainly used for treating ichthyosis and xerodermia and a process thereof. The formula consists of the following components: urea, light liquid paraffin, alpha-hydroxypropionic acid, glyceryl monostearate, glycerol distearate, concentrated ammonium liquid, polyoxyl (40) stearate, cholesterol, glycerol, albolene, octadecanol and purified water. The invention aims to provide the formula of an external medicine mainly used for treating ichthyosis and xerodermia and the process thereof, wherein the external medicine is high in stability and long in service life, can overcome temperature and light decomposition, is safe and is not irritant.

Description

Technical field: [0001] The invention relates to a preparation prescription and process of an external medicine, which is mainly used for mainly treating ichthyosis and dry skin. Background technique: [0002] Ichthyosis and xeroderma are caused by superficial skin fungi and occupational skin diseases. The symptoms are dry skin, and severe cases can cause chapped, bleeding and secondary infection. At present, the treatment methods mainly use lactic acid salt as the main ingredient to make lotions, the curative effect is not long-lasting, and the medicine is easy to lose; some creams with urea as the main medicine are oil-in-water type, the drug effect stability is not good, and they are easy to be affected. The decomposition of temperature and light affects the therapeutic effect. The purpose of the present invention is to provide a safe and non-irritating external medicine formulation and process for treating ichthyosis and dry skin with high stability and long shelf life,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/17A61K47/44A61K47/10A61K47/14A61P17/16
Inventor 乔风敏王立强陈良海
Owner 福建太平洋制药有限公司
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