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External medicinal formula mainly used for treating ichthyosis and xerodermia and process thereof

A technology for dry skin and external use, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, skin diseases, etc., and can solve problems such as decomposition, poor stability of drug efficacy, and impact on treatment effects.

Active Publication Date: 2012-09-12
福建太平洋制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment methods mainly use lactic acid salt as the main ingredient to make lotions, the curative effect is not long-lasting, and the medicine is easy to lose; some creams with urea as the main medicine are oil-in-water type, the drug effect stability is not good, and they are easy to be affected. The decomposition of temperature and light affects the therapeutic effect

Method used

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  • External medicinal formula mainly used for treating ichthyosis and xerodermia and process thereof
  • External medicinal formula mainly used for treating ichthyosis and xerodermia and process thereof
  • External medicinal formula mainly used for treating ichthyosis and xerodermia and process thereof

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Experimental program
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Embodiment Construction

[0015] 150g of urea, 120g of α-hydroxypropionic acid, 30g of glyceryl mono- and distearate, 75g of concentrated ammonia solution, 10g of polyoxyl stearate (40), 30g of cholesterol, 90g of glycerin, 180g of white petrolatum, light liquid 180g of paraffin wax, 20g of stearyl alcohol, and purified water are added to 1000g.

[0016] 1. Preparation of the main drug: Weigh 120g of a-hydroxypropionic acid and 75g of concentrated ammonia solution, slowly add the concentrated ammonia solution to the a-hydroxypropionic acid and stir constantly to make the acid-base neutralization reaction complete (stop stirring, static After standing for 20 minutes, no air bubbles are generated), use a pH test paper to detect the pH of the solution to 4.0-6.0, and then add 150g of urea and stir until dissolved.

[0017] 2. Preparation of the oil phase: weigh 30g of cholesterol, 20g of stearyl alcohol, 180g of white petrolatum, 30g of glyceryl mono / distearate, 180g of light liquid paraffin, and 10g of polyox...

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Abstract

The invention relates to an external medicinal formula mainly used for treating ichthyosis and xerodermia and a process thereof. The formula consists of the following components: urea, light liquid paraffin, alpha-hydroxypropionic acid, glyceryl monostearate, glycerol distearate, concentrated ammonium liquid, polyoxyl (40) stearate, cholesterol, glycerol, albolene, octadecanol and purified water. The invention aims to provide the formula of an external medicine mainly used for treating ichthyosis and xerodermia and the process thereof, wherein the external medicine is high in stability and long in service life, can overcome temperature and light decomposition, is safe and is not irritant.

Description

Technical field: [0001] The present invention is a preparation prescription and process of a medicine for external use, and is mainly an external medicine for treating ichthyosis and dry skin. Background technique: [0002] Ichthyosis and dry skin are caused by superficial skin fungi and occupational skin diseases. The symptoms are dry skin. In severe cases, it can cause chapped, bleeding and secondary infections. At present, the treatment method mainly uses lactate as the main material, made into lotion, the curative effect is not long-lasting, and the medicine is easy to lose; some creams with urea as the main medicine are oil-in-water type, which is not stable and easy to suffer The decomposition of temperature and light affects the treatment effect. The purpose of the present invention is to provide a formula and process for externally applied medicine for the treatment of ichthyosis and dry skin that are safe and non-irritating, with high stability, long shelf life, tempera...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/17A61K47/44A61K47/10A61K47/14A61P17/16
Inventor 乔风敏王立强陈良海
Owner 福建太平洋制药有限公司
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