Chinese medicinal enteric capsules for treating medium-term and advanced tumors and chronic hepatitis B and preparation method for capsules

A technology of enteric-coated capsules and chronic hepatitis B, which is applied in the direction of antineoplastic drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve the problems of unsatisfactory curative effect of preparations, few active ingredients, and toxic and side effects

Active Publication Date: 2012-09-19
陕西东泰制药有限公司
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Problems solved by technology

The inventors found that "using 85% ethanol to extract the dregs and extracting them with water, centrifuging respectively" can extract some fat-soluble components bufotoxin and water-soluble components indole alkaloids in some dry toad skins to remove impurities, but The inventor finds that the active ingredients extracted by the process are few, the extraction rate of the process is low, the curative effect of the prepared preparation is not satisfactory, and there are some toxic and side effects

Method used

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  • Chinese medicinal enteric capsules for treating medium-term and advanced tumors and chronic hepatitis B and preparation method for capsules
  • Chinese medicinal enteric capsules for treating medium-term and advanced tumors and chronic hepatitis B and preparation method for capsules
  • Chinese medicinal enteric capsules for treating medium-term and advanced tumors and chronic hepatitis B and preparation method for capsules

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Embodiment Construction

[0090] 1. Take 3500g of dried toad skin, cut it into pieces, wash it, add 60% ethanol for reflux extraction twice, add 6 times the amount of ethanol for the first time, soak for 2 hours first, then reflux for 1 hour, add 4 times the amount for the second time Ethanol, reflux extraction for 30 minutes, combined extracts, filtered, dregs for later use, the filtrate was centrifuged at 4000r / min for 30min, and the supernatant was collected to recover ethanol until it had no alcohol smell, and a clear ointment was obtained for later use; extract dregs with alcohol, add water Decoct twice, add 8 times the amount of water for the first time, decoct for 1 hour, add 6 times the amount of water for the second time, decoct for 45 minutes, combine the decoction, filter, and centrifuge the filtrate at 4000r / min for 30 minutes, take The supernatant is concentrated to a clear paste with a relative density of 1.08-1.12, combined with the above clear paste, spray-dried into a fine powder, and t...

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Abstract

The invention discloses Chinese medicinal enteric capsules for treating medium-term and advanced tumors and chronic hepatitis B and a preparation method for the capsules. The capsules are prepared by processing a medicinal active ingredient prepared from dried toad skin and a medicinally acceptable carrier in a certain ratio, wherein the medicinal carrier consists of sodium carboxymethylcelluloseand starch. Compared with the prior art, the Chinese medicinal enteric capsules and the preparation method have the advantages that 60 percent ethanol is adopted for reflux extraction, so that the content of indole alkaloid and toad venom lactone which serve as active ingredients is improved, the curative effect is enhanced, the toxic or side effect of medicaments is reduced, the administration effect of a patient is remarkable, and the capsules are safe and convenient.

Description

technical field [0001] The invention relates to a traditional Chinese medicine enteric-coated capsule for treating advanced tumors and chronic hepatitis B and a preparation method thereof, belonging to the technical field of pharmacy. technical background [0002] Indole alkaloids, the water-soluble components of dried toad skin, can regulate immunity, inhibit the replication of HBV and DNA, have strong antiviral effect, and have a good therapeutic effect on hepatitis B. The fat-soluble components bufolides in dried toad skin have significant anti-tumor effects. On January 14, 2009, the Chinese Patent Gazette disclosed the name declared by the applicant as "a traditional Chinese medicine for treating middle and advanced tumors and chronic hepatitis B." Preparation and preparation method thereof", the patent application with the publication number CN 101342194A, the preparation method of the traditional Chinese medicine preparation is mainly as follows: the dregs are extracte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61P1/16A61P31/20A61P35/00A61K35/65
Inventor 罗川
Owner 陕西东泰制药有限公司
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