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Application of salidroside in treating C-type fanconi anemia

A technology of salidroside and anemia, which is applied in the field of medicine, can solve the problems of strong toxicity and side effects, achieve the effect of small toxicity and side effects, strong effect, and meet the clinical needs

Inactive Publication Date: 2013-01-02
SOUTH CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there is hormone therapy, which is effective for most cases, but has strong side effects

Method used

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  • Application of salidroside in treating C-type fanconi anemia
  • Application of salidroside in treating C-type fanconi anemia
  • Application of salidroside in treating C-type fanconi anemia

Examples

Experimental program
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Effect test

Embodiment Construction

[0010] The specific implementation of the present invention will be described in further detail below in conjunction with the examples.

[0011] Example Effect of salidroside on the formation of bone marrow hematopoietic colony in type C Fanconi anemia mice

[0012] 1) Experimental animals and handling

[0013] Type C Fanconi anemia mouse Fancc - / - and sibling normal mouse Fancc + / + is through Fancc + / -– Mice (provided by Dr. M. Buchwald, University of Toronto, Toronto, Ontario, Canada, genetic background C57BL / 6, CD45.2) were mated, and the offspring were genotyped by PCR technology. All experiments used mice aged 8-20 weeks. Experimental points SD / Fancc - / - 、DPBS / Fancc - / - 、SD / Fancc + / + 、DPBS / Fancc + / + There are 4 groups in total. Salidroside (PhytoLab GmbH & Co. KG, dose 75, 100, 150 mg / kg) was intraperitoneally injected 4 times in 2 weeks. At the same time, the control group was intraperitoneally injected with an equal volume of DPBS (Dulbecco’s Phosphate Buffer...

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Abstract

The invention discloses application of a compound of salidroside in preparing pharmaceuticals for treating C-type fanconi anemia. The compound has stronger promotion effects on hematopoietic colony formation, can be used for developing the pharmaceuticals for treating C-type fanconi anemia, meets the clinical demands, and has excellent market value.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the application of salidroside in the preparation of medicines for treating type C Fanconi anemia. Background technique [0002] Salidroside (salidroside, SD) is also called salicyloside and salidroside, and its chemical name is 2-(p-hydroxyphenyl) ethyl β-D-glucopyranoside. The compounds extracted and isolated from the dry roots and rhizomes of R.hodiola Sacha-linensis.A.Bor. or Rhodiola crenulata HOhba. Studies have shown that salidroside can reduce the degree of cerebral edema after global cerebral ischemia-reperfusion in rats, alleviate the abnormal metabolism of free radicals in the hippocampus, and improve cognitive function; it can relieve oxidative damage in fatigued mice; it has anti-Coxsackie (Coxsackie) The effect of virus; prevent Alzheimer's disease (AD) by protecting neuronal PC12 cells; can resist H 2 o 2 Induced apoptosis and protect the nervous s...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61P7/06
Inventor 李续娥杜玮庞启深
Owner SOUTH CHINA NORMAL UNIVERSITY
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