Application of Houttuynoid C in medicine for preventing and treating liver injury

A technology of liver damage and drugs, applied in the field of Houttuynoid C, can solve the problems of liver damage, aggravation, and elevation, and achieve the effect of strong therapeutic effect and outstanding substantive characteristics

Active Publication Date: 2013-01-09
海门市知舟工业设计有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4. Other reasons: primary and secondary liver tumors, liver congestion caused by cardiac insufficiency, certain congenital liver diseases, high-priced intravenous nutrition, etc., can all cause liver damage to varying degrees. The early manifestations of these liver damage are often Elevation of ALT (transaminase) or bilirubin, if the cause is not eliminated, the liver damage will be further aggravated

Method used

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  • Application of Houttuynoid C in medicine for preventing and treating liver injury
  • Application of Houttuynoid C in medicine for preventing and treating liver injury
  • Application of Houttuynoid C in medicine for preventing and treating liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: the preparation of compound Houttuynoid C tablet involved in the present invention:

[0012] Take 20 grams of compound Houttuynoid C, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0013] Embodiment 2: the preparation of compound Houttuynoid C capsule of the present invention:

[0014] Get 20 grams of compound Houttuynoid C, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0015] The following pharmacodynamic experiments will further illustrate its drug activity.

[0016] The following are some pharmacological experimental data:

experiment example 1

[0017] Experimental example 1. The effect of Houttuynoid C on preventing and treating liver injury

[0018] (1) Protective effect of Houttuynoid C on D-galactosamine (D-GalN)-induced acute liver injury in mice

[0019] The mice were divided into 5 groups, and the control group was intragastrically administered with normal saline (0.3 mL·d -1 ), for 7 consecutive days, on the 7th day intraperitoneal injection of normal saline (0.15mL·10g -1 ); D-GalN, Houttuynoid C (1.5, 3.0, 6.0 mg·kg -1 ) Each group was given intragastric administration of normal saline and different concentrations of Houttuynoid C (0.3 mL·d -1 ), for 7 consecutive days, on the 7th day intraperitoneal injection of D-GalN (800mg·kg -1 , 0.15mL·10g -1 ), blood was collected after 16 hours, and AST and ALT activities were measured.

[0020] Table 1 Protective effect of Houttuynoid C on acute liver injury induced by D-GalN

[0021]

[0022] Note: 1) p2) p<0.01 vs D-GalN group

[0023] It can be seen f...

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PUM

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Abstract

The inventor discovers that Houttuynoid C has a prevention effect on mice acute liver injury induced by D-galactosamine (D-GalN) and has a prevention effect on mice acute liver injury induced by carbon tetrachloride (CCl4) through a pharmacological study. Therefore, Houttuynoid C can be utilized to prepare the medicines for preventing and treating liver injury or hepatitis. Application of Houttuynoid C in preparation of the medicine for preventing and treating liver injury provided by the invention is disclosed firstly. The skeleton type belongs to new skeleton type, and the activity of Houttuynoid E on the treatment effect of liver injury is unexpectedly strong; and the probability that any revelation is provided by other compounds does not existe, Houttuynoid C has the excellent substantive features, and Houttuynoid C obviously has a remarkable progress when being used fo preventing liver injury.

Description

technical field [0001] The present invention relates to Houttuynoid C, in particular, relates to Houttuynoid C used as medicine for preventing and treating liver damage. technical background [0002] There are multiple reasons for causing liver damage: 1. Viral infection: caused by a variety of hepatitis viruses, with strong infectivity, complex transmission routes, wide epidemic range, and high incidence rate. 2. Drugs or chemical poisons: Many drugs and chemical poisons can cause liver damage, drug-induced hepatitis or toxic hepatitis. 3. Alcoholism: Alcohol damages the liver very seriously. The consequences of the damage include alcoholic hepatitis, alcoholic fatty liver, and alcoholic cirrhosis, mainly due to the toxicity of alcohol (ethanol) and its metabolite acetaldehyde on liver cells. caused by direct damage. 4. Other reasons: primary and secondary liver tumors, liver congestion caused by cardiac insufficiency, certain congenital liver diseases, high-priced intrav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P1/16
Inventor 俞骁施桦吴俊华
Owner 海门市知舟工业设计有限公司
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