Molecular marker for detecting susceptibility of ovarian cancer

A technology for ovarian cancer and susceptibility, applied in the field of de polymor, can solve the problems of no GADD45A gene, no GADD45A gene correlation, etc., and achieve the effect of strong specificity and simple detection
CN102864236BActive Publication Date: 2014-04-16SHANDONG UNIV QILU HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG UNIV QILU HOSPITAL
Publication Date
2014-04-16

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Abstract

The invention discloses a molecular marker for detecting susceptibility of ovarian cancer. Nucleotide sequences of the molecular marker are shown in SEQ ID NO.1, and mononucleotide polymorphism, namely T>C is present at 1506th site. A kit for detecting susceptibility of ovarian cancer comprises a pair of specific primers having sequences in SEQ ID NO.2 and SEQ ID NO.3. A method for detecting presence of mononucleotide polymorphism in GADD45A (growth arrest and DNA-damage-inducible protein 45 alpha) gene in a sample in vitro includes: firstly, amplifying the GADD45A gene in the sample by the specific primers to obtain an amplification product; secondly, subjecting the amplification product to sequence determination, and detecting presence of mononucleotide polymorphism, namely 1506T>C, in the amplification product. The method is simple, accurate and fast in detection and high in specificity, and is important to effectively implementing early diagnosis, early treatment and individual prevention and treatment to high risk groups or susceptible individuals and patients with ovarian cancer.
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Description

technical field

[0001] The present invention relates to a molecular marker, a kit and a detection method for detecting the susceptibility of ovarian cancer, in particular to the single nucleotide polymorphism (single nucleotide polymorphism, SNP) of GADD45A gene and its correlation with ovarian cancer The properties, and methods and kits for detecting these SNPs belong to the fields of molecular biology and medicine. Background technique

[0002] Ovarian cancer is the most lethal tumor of the female reproductive system. In 2008, there were 225,500 new cases and 140,200 deaths worldwide. Due to insidious onset and inconspicuous symptoms, most patients are diagnosed at an advanced stage. The 5-year survival rate of patients with advanced ovarian cancer is only about 30-45%, and the prognosis is poor. However, the 5-year survival rate of patients with early ovarian cancer is as high as 90%. It reminds us that the key to improving the prognosis and survival of ovarian cancer pa...

Claims

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