Traditional Chinese medicine composition particles for clearing heat and expelling damp, and preparation method thereof

A heat-clearing and damp-dampening, composition technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of low extraction yield of active ingredients, long extraction process, poor batch stability, etc., to achieve guaranteed Batch stability, short extraction process, and the effect of enhancing the immune function of the body

Active Publication Date: 2013-09-04
TEYI PHARMACEUTICAL GROUP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are some problems with this process, such as 1) the extraction yield of the active ingredients of the volatile oil and water extract is low, and the active ingredients are unstable; 2) the extraction process is long; 3) the concentration is large and the energy consumption is large
As a result, the production cost increases, the production cycle is long, the batch stability is not good, and the efficacy of the medicine is affected

Method used

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  • Traditional Chinese medicine composition particles for clearing heat and expelling damp, and preparation method thereof
  • Traditional Chinese medicine composition particles for clearing heat and expelling damp, and preparation method thereof
  • Traditional Chinese medicine composition particles for clearing heat and expelling damp, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A traditional Chinese medicine composition granule for clearing away heat and dampness, the preparation method of which is as follows:

[0032] 1) Extraction: Weigh 30g of herb Atractylodes atractylodis, 150g of wild chrysanthemum, and 30g of tangerine peel, crush them into 60 meshes, and use supercritical CO 2 The extraction device extracts volatile oil, using ethanol as entrainer, controlling pressure 25MPa, temperature 45°C, CO 2 The flow rate is 2-3L / min, and the extraction time is 3.5 hours to obtain 48ml of volatile oil extract;

[0033] 2) Extraction and concentration: Weigh 60g of Codonopsis pilosula, 90g of capillary, 150g of Radix Astragali, and 90g of Radix Astragali, and put them into the extraction device together with the dregs of Atractylodes atractylodes, wild chrysanthemum, and tangerine peel after extracting the volatile oil. 8 times the amount of medicinal materials (the amount of medicinal materials refers to the total weight of medicinal materials ...

Embodiment 2

[0038] A traditional Chinese medicine composition granule for clearing away heat and dampness, the preparation method of which is as follows:

[0039] 1) Extraction: Weigh 20g of herb Atractylodes atractylodis, 100g of wild chrysanthemum, and 20g of tangerine peel, crush them into 60 meshes, extract volatile oil with a supercritical CO2 extraction device, use ethanol as entrainer, control pressure 20MPa, temperature 40°C, CO2 flow rate 2 -3L / min, extraction time 3.5 hours to get 33ml of volatile oil extract;

[0040]2) Extraction and concentration: Weigh 45g of Codonopsis pilosula, 75g of capillary chen, 110g of root plum, and 75g of astragalus, and put them into the extraction device together with the dregs of atractylodes rhizome, wild chrysanthemum, and tangerine peel after extracting the volatile oil. Water with 6 times the amount of medicinal materials (the amount of medicinal materials refers to the total weight of medicinal materials Atractylodes atractylodis, wild chry...

Embodiment 3

[0045] A traditional Chinese medicine composition granule for clearing away heat and dampness, the preparation method of which is as follows:

[0046] 1) Extraction: Weigh 40g of herb Atractylodes atractylodis, 200g of wild chrysanthemum, and 40g of tangerine peel, crush them into 60 meshes, extract volatile oil with a supercritical CO2 extraction device, use ethanol as entrainer, control pressure 30MPa, temperature 50°C, CO2 flow rate 2 -3L / min, extraction time 3.5 hours to get 65ml of volatile oil extract;

[0047] 2) Extraction and concentration: Weigh 70g of Codonopsis pilosula, 120g of capillary, 190g of Radix Astragalus, and 120g of Radix Astragali, and put them into the extraction device together with the dregs of Atractylodes atractylodes, wild chrysanthemum, and tangerine peel after extracting volatile oil. Water with 10 times the amount of medicinal materials (the amount of medicinal materials refers to the total weight of medicinal materials Atractylodis Rhizome, Wi...

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Abstract

The invention provides a preparation method of traditional Chinese medicine composition particles for clearing heat and expelling damp, and traditional Chinese medicine composition particles for clearing heat and expelling damp prepared by the method. The preparation method comprises the following steps of: extracting volatile oil by a supercritical extraction method, extracting concentrated water-soluble active ingredients in a recycling way by means of thermal reflow, and further preparing the composition particles by utilizing the prepared condensed extract. The preparation method provided by the invention has the characteristics of being high in extraction efficiency, short in technological process, mild in preparation conditions, and less in energy consumption. The prepared traditional Chinese medicine composition particles for clearing heat and expelling damp is high in active ingredient content.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for clearing away heat and dampness, in particular to a preparation process of granules of the traditional Chinese medicine composition for clearing away heat and dampness. Background technique [0002] An existing heat-clearing and damp-dispelling granule composed of natural Chinese herbal medicines Codonopsis codonopsis, capillary root, root plum, astragalus, herb atractylodes, wild chrysanthemum and tangerine peel has the functions of clearing away heat and dampness, replenishing qi and promoting body fluid. This heat-clearing and damp-dispelling granule can be used for fatigue of limbs, loss of appetite, body heat and dry mouth caused by heat-dampness pathogens. Among them, Atractylodes atractylodis, wild chrysanthemum, and tangerine peel are rich in volatile oil components. The main components of volatile oil include atractylodesin, atractylodes alcohol, atractylone, chrysanthemum...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61P1/14A61P43/00
Inventor 许丹青
Owner TEYI PHARMACEUTICAL GROUP CO LTD
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