Application of artesunate in preparation of medicine used for inhibiting migration of hepatic stellate cells

A technology of hepatic stellate cells and artesunate, applied in the application field of medicine, can solve problems such as no relevant reports

Inactive Publication Date: 2013-03-27
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the role of artesunate in inhibiting the migration of hepatic stellate cells

Method used

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  • Application of artesunate in preparation of medicine used for inhibiting migration of hepatic stellate cells
  • Application of artesunate in preparation of medicine used for inhibiting migration of hepatic stellate cells
  • Application of artesunate in preparation of medicine used for inhibiting migration of hepatic stellate cells

Examples

Experimental program
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Effect test

Embodiment 1

[0066] The artesunate of the present invention is made into tablets according to methods known to those skilled in the art. Artesunate tablets, each containing 50 mg of artesunate, 60 mg of microcrystalline cellulose, 20 mg of micropowdered silica gel, 10 mg of lactose, and 0.7 mg of magnesium stearate. Usage: 1 tablet each time, 2-3 times a day, 5-6 days a week, every 3-4 weeks as a course of treatment.

Embodiment 2

[0068] The artesunate of the present invention is made into capsules according to methods known to those skilled in the art. Artesunate capsules, each containing 50mg of artesunate. Usage: 1 capsule each time, 2-3 times a day, 5-6 days a week, every 3-4 weeks as a course of treatment.

Embodiment 3

[0070] The artesunate of the present invention is prepared into granules according to methods known to those skilled in the art. Artesunate granules, each bag contains 50mg of artesunate, 60mg of microcrystalline cellulose, 20mg of micropowder silica gel, 0.7mg of stearic acid, and 20mg of lactose. Usage: 1 bag each time, 2-3 times a day, 5-6 days a week, every 3-4 weeks as a course of treatment.

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Abstract

The invention discloses an application of artesunate in preparation of medicine used for inhibiting migration of hepatic stellate cells. According to the application disclosed by the invention, a PDGF (platelet derived growth factor)-induced human hepatic stellate cell strain (LX-2) migration screening platform is designed, and the fact that artesunate with the concentration of being 10<-4>-10<-7>mol/L can inhibit migration of PDGF-induced hepatic stellate cells (HSCs) is found.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to the application of artesunate in the preparation of medicines for inhibiting the migration of hepatic stellate cells. Background technique [0002] Artesunate, synonym: artesunate, molecular formula: C 19 h 28 o 8 ;Physical properties: white crystal, melting point 1290℃-1400℃, odorless, bitter taste. Soluble in chloroform, soluble in acetone, slightly soluble in methanol or ethanol, almost insoluble in water. Artesunate is derived from the leaves of Artemisia annua L. Action and use: It has a strong killing effect on Plasmodium asexual body, and can quickly control the onset of malaria. In the treatment of vivax malaria with artesunate, the average negative turn time of falciparum is faster than that of chloroquine, and no toxic side effects have been seen in clinical treatment. [0003] Artesunate is one of the derivatives of artemisinin. Its chemic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/357A61P1/16
Inventor 徐列明张展
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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