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Preparation method and application of yin tonifying and calming tablet

A technology of Yinzhenjing Tablets and Angelica, which is applied in the field of preparation of Yangyinjing Tablets, can solve the problems of large dosage for patients, affect clinical application, and many impurities, and achieve the effect of reducing dosage

Inactive Publication Date: 2013-03-27
黄传峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Yangyin sedative tablets, but the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient Taking it seriously affects the clinical application of this product

Method used

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  • Preparation method and application of yin tonifying and calming tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 75g of Angelica, 57g of Ophiopogon japonicus, 48g of Schisandra chinensis, 39g of Radix Polygoni Multiflori, 39g of Rehmannia glutinosa, 75g of Poria cocos, 18g of Baiziren, 75g of Codonopsis pilosula, 93g of mother of pearl, 57g of scrophulariaceae, 57g of salvia miltiorrhiza, 39g of polygala, 39g of platycodon, 10.2g of cinnabar, Add angelica and cypress kernels to a CO2 supercritical extractor, use ethanol as an entrainer, the volume percentage of the entrainer to the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained for later use; the rest of the traditional Chinese medicine is taken, pulverized, added with 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 400W, and the extraction is performed twice. Combine the extracts for 4 minutes eac...

Embodiment 2

[0028] Take 75g of Angelica, 57g of Ophiopogon japonicus, 48g of Schisandra chinensis, 39g of Radix Polygoni Multiflori, 39g of Rehmannia glutinosa, 75g of Poria cocos, 18g of Baiziren, 75g of Codonopsis pilosula, 93g of mother of pearl, 57g of scrophulariaceae, 57g of salvia miltiorrhiza, 39g of polygala, 39g of platycodon, 10.2g of cinnabar, Add Angelica and Baiziren to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction, with an extraction power of 600W, and extracted twice. 8 minutes each time, combine the extracts, concentrate, a...

Embodiment 3

[0031] Take 75g of Angelica, 57g of Ophiopogon japonicus, 48g of Schisandra chinensis, 39g of Radix Polygoni Multiflori, 39g of Rehmannia glutinosa, 75g of Poria cocos, 18g of Baiziren, 75g of Codonopsis pilosula, 93g of mother of pearl, 57g of scrophulariaceae, 57g of salvia miltiorrhiza, 39g of polygala, 39g of platycodon, 10.2g of cinnabar, Add Angelica and Baiziren to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. Combine the extracts for 6 minutes each time, con...

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Abstract

The invention provides a preparation method of a yin tonifying and calming tablet, which is prepared from crude drugs including 75g of angelica sinensis, 57g of radix ophiopogonis, 48g of schisandra chinensis, 39g of vine of multiflower knotweed, 39g of rhizome rehmanniae, 75g of poria cocos, 18g of platycladi seed, 75g of codonopsis pilosula, 93g of concha margaritiferausta, 57g of radix scrophulariae, 57g of salvia miltiorrhiza, 39g of polygala tenuifolia, 39g of platycodon grandiflorum and 10.2g of cinnabar through supercritical extraction and microwave extraction, so that the content of ferulic acid is greatly improved. The invention also provides the application of the yin tonifying and calming tablet in preparing a medicine for restraining proliferation of mice leukemia cell, L1210 cell.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of a Yangyin calming tablet. Background technique [0002] Yangyin Zhenjing Tablets are recorded in the standard WS3-B-0360-90 of the Ministry of Health, consisting of 75g of Angelica, 57g of Ophiopogon japonicus, 48g of Schisandra, 39g of Shouwu Teng, 39g of Rehmannia glutinosa, 75g of Poria cocos, 18g of Baiziren, 75g of Codonopsis pilosula, 93g of mother-of-pearl, Scrophulariaceae 57g, Salvia miltiorrhiza 57g, Polygala 39g, Campanulaceae 39g, and cinnabar 10.2g are made as raw materials, which can nourish yin and blood, calm the nerves and calm the nerves. For insufficiency of effort, stupefaction, forgetfulness, restlessness, palpitation and insomnia. [0003] In the prior art, there is no report about the use of supercritical and microwave technology in the extraction and preparation of Yangyin calming t...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/20A61P35/02A61P25/20A61P9/06A61P25/28A61K35/56A61K33/28A61K35/618
Inventor 不公告发明人
Owner 黄传峰
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