Andrographis paniculata extract and method for preparing same

A technology of Andrographis paniculata extract, applied in the field of Andrographis paniculata extract and its preparation, can solve the problems of failure to remove impurity components, difficulty in retaining the active ingredients of Andrographis paniculata, and affecting the quality of Andrographis paniculata preparations, so as to avoid decomposition loss, maintain antibacterial and anti-inflammatory activities, and The effect on industrial mass production

Inactive Publication Date: 2013-04-03
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the current industrialized production, single-effect or double-effect thermal concentration process and drying process are used for concentration. Therefore, the active ingredient in the Churographis paniculata tablets produced according to the Pharmacopoeia process - the total andrographolide component has been eliminated in the production process. ("Changes in content of dehydroandrographolide in the production process of Chuanxinlian tablets", Chinese Journal of Traditional Chinese Medicine, 2002, 12, 36-38), it can be seen that this simple production technology not only does not remove impurities, but also It is difficult to keep the active ingredients in Andrographis paniculata, which has seriously affected the quality of Andrographis paniculata preparations. For this reason, further research on how to effectively improve the yield of active ingredients such as andrographolide and the large-scale production preparation technology for removing impurity components such as pigments to the greatest extent is necessary. It is very important to ensure the quality and curative effect of Andrographis paniculata preparation

Method used

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  • Andrographis paniculata extract and method for preparing same
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  • Andrographis paniculata extract and method for preparing same

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Take 10kg of Andrographis paniculata, first crush it into coarse grains, then ball mill it into superfine powder particles, extract twice by percolation with 10 times the weight of 85% ethanol (v / v), each extraction time is 24h; after the extraction, filter, The two filtrates were combined to obtain Andrographis paniculata extract, which was filtered through a microfiltration membrane (using PP cotton) to remove suspended particles and other impurities. At the same time, it can be seen that PP cotton adsorbed a large amount of pigments and other components; the filtrate was purified by activated carbon fiber column, further Impurities such as pigments are removed, and the purified solution is driven by a high-pressure pump (the working pressure of the high-pressure pump is kept between 0.6 and 0.9 MPa), and the Andrographis paniculata extract is concentrated by nanofiltration membrane circulation and pressure to 1 / 10 of the original volume , the obtained concentrated sol...

Embodiment 2

[0036]Take 50 kg of Andrographis paniculata, first crush it into coarse grains, and then ball mill it into superfine powder particles, extract twice by cold soaking in 85% ethanol (v / v) with 10 times the weight, and the extraction time is 24 hours each time; after the extraction, filter, The two filtrates were combined to obtain Andrographis paniculata extract, which was filtered through a microfiltration membrane (using PP cotton) to remove suspended particles and other impurities. At the same time, it can be seen that PP cotton adsorbed a large amount of pigments and other components; the filtrate was purified by activated carbon fiber column, further Impurities such as pigments are removed, and the purified solution is driven by a high-pressure pump (the working pressure of the high-pressure pump is kept between 0.6 and 0.9 MPa), and the Andrographis paniculata extract is concentrated by nanofiltration membrane circulation and pressure to 1 / 10 of the original volume , the ob...

Embodiment 3

[0038] Take 5 kg of Andrographis paniculata, first crush it into coarse grains, and then ball mill it into superfine powder particles, extract twice by percolation with 85% ethanol (v / v) of 10 times the weight, and the extraction time is 24 hours each time; after the extraction, filter, The two filtrates were combined to obtain Andrographis paniculata extract, which was filtered through a microfiltration membrane (using PP cotton) to remove suspended particles and other impurities. At the same time, it can be seen that PP cotton adsorbed a large amount of pigments and other components; the filtrate was purified by activated carbon fiber column, further Impurities such as pigments are removed, and the purified solution is driven by a high-pressure pump (the working pressure of the high-pressure pump is kept between 0.6 and 0.9 MPa), and the Andrographis paniculata extract is concentrated by nanofiltration membrane circulation and pressure to 1 / 10 of the original volume , the obt...

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Abstract

The invention discloses an andrographis paniculata extract and a method for preparing the same. The andrographis paniculata extract comprises 32.3- 40.5% by mass of andrographolide and 2.23-5.52% by mass of dehydroandrographolide. The method comprises the following steps: grinding the andrographis paniculata by adopting the ball milling technology, extracting by ethanol, filtrating the obtained extract by a micro-filtration memebrane, purifying by activated carbon fiber, concentrating by a nanofiltration membrane, eluting by a macroporous resin, spraying and drying to obtain the andrographis paniculata extract. The active components such as the andrographolide in the andrographis paniculata which is a medicinal herb are kept to the maximum extent, the impurities such as the pigment in the andrographis paniculata are removed, and the strong anti-bacterial and anti-inflammatory activities of the andrographis paniculata are retained. The method of preparing the andrographis paniculata extract is easy to operate, omits the step of heating, consumes the least energy for preparation and is suitable for industrial mass production.

Description

technical field [0001] The invention relates to a preparation method of a medicine derived from a plant raw material, in particular to an andrographis paniculata extract and a preparation method thereof. Background technique [0002] Andrographis paniculata Andrographis paniculata The whole plant of (Burm.f.) Nees has the effects of clearing heat and detoxifying, cooling blood and reducing swelling. It is widely distributed in Guangdong and has a long history of cultivation. It is the raw material of many famous Chinese patent medicines such as Chuanxinlian injection, Chuanhuning preparation, Chuanxinlian tablet, Xiaoyan Lidan tablet, and compound Chuanxinlian tablet. Its active ingredients are andrographolide and other ingredients. In addition to these active ingredients, there are many other types of chemical ingredients such as pigments with low content. Active ingredients such as andrographolide are unstable when heated and are easy to decompose. Prolonged heating will...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/19A61P31/04
Inventor 曾令杰
Owner GUANGDONG PHARMA UNIV
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