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Polypeptide and application of polypeptide in preparation of drug used for treating depression

A depression and antidepressant technology, applied in drug combinations, peptides, pharmaceutical formulations, etc., can solve problems such as unresponsiveness to patients' treatment methods, and achieve the effects of shortening immobility time, broad application prospects, and long duration of action

Active Publication Date: 2013-05-15
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, these drugs take weeks to months to work, and one third of patients do not respond to any treatment

Method used

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  • Polypeptide and application of polypeptide in preparation of drug used for treating depression
  • Polypeptide and application of polypeptide in preparation of drug used for treating depression
  • Polypeptide and application of polypeptide in preparation of drug used for treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1, the polypeptide of the present invention significantly reduces the immobility time in the forced swimming test of rats

[0026] 1. Experimental method

[0027] Sprague-Dawley (SD) male rats with a body weight of 220-240g (purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.) were selected, and the temperature was 22±2°C, the humidity was 50%±10%, and the 12h / 12h circadian rhythm In the controlled animal room, after 4 days of feeding and drinking freely, the rats were randomly divided into 4 groups (denoted as vehicle control group, polypeptide A91A96 group, polypeptide R91A96 group and venlafaxine group, with 10 rats in each group). ), start dosing (denoted as figure 1 On the 0th day), the 5min open field test was performed on the 8th day and the number of crawling frames was recorded, and the 5min forced swimming test was performed on the 9th day and the immobility time was recorded. The experimental process is as follows figure 1 ...

Embodiment 2

[0039] Example 2. The polypeptide of the present invention significantly reversed the decline in sugar water preference in rats caused by chronic unpredictable stress

[0040] 1. Experimental method

[0041] The experimental process is as follows Figure 4 shown. Sprague-Dawley (SD) male rats with a body weight of 220-240g (purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.) were selected, and the temperature was 22±2°C, the humidity was 50%±10%, and the 12h / 12h circadian rhythm After 4 days of feeding and drinking freely in the controlled animal room, the rats were randomly divided into 5 groups (10 rats in each group) and processed as follows:

[0042] a) Vehicle control group: in Figure 4 A single subcutaneous injection was performed on the indicated day 0, and each rat was injected with a mixture of drug vehicle (that is, an equal volume of PBS (0.1M, pH 7.4) and Freund's complete adjuvant (purchased from Sigma-Aldrich) ) 0.5mL;

[0043] b) V...

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Abstract

The invention discloses a polypeptide and an application of the polypeptide in preparation of a drug used for treating depression. The polypeptide is a peptide fragment shown as a sequence 1 or 2 in a sequence table. Experiments prove that once subcutaneous injection drug administration of the polypeptide shown as the sequence 1 or 2 in the sequence table is 100 micrograms / pc, in a rat forced swimming test, compared with a solvent control group and a venlafaxine group, dead time of a rat in forced swimming can be obviously shortened, and in a chronic unpredictability stress test, decrease of sweet water preference value caused by chronic unpredictability stress can be reversed. The polypeptide provided by the invention can immediately take effect after a single drug administration, duration of action is long, and the polypeptide still can treat depression-like behaviours tested on a 36th day after the drug administration. The invention provides a new drug and therapeutic method for preventing and / or treating depression and has a wide application prospect.

Description

technical field [0001] The invention relates to a polypeptide and its application in the preparation of drugs for treating depression. Background technique [0002] Depression is a high incidence of emotional disorder mental disease, which seriously threatens human health and social development. Depression is caused by a series of interactions between genes and the environment, mainly manifested as low mood, low interest, anhedonia, despair, helplessness, guilt, etc., accompanied by severe anxiety and suicidal tendencies. At present, the treatment drugs for depression are mainly based on the hypothesis of monoamine substances, and commonly used clinical treatment methods include drug therapy targeting monoamine transmitters and electroshock therapy. Unfortunately, these drugs take weeks to months to work, and a third of patients do not respond to any treatment. Therefore, researching new and effective drugs for the treatment and prevention of depression is the key to the t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/08A61K38/10A61P25/24
Inventor 陆林孙成玉孟适秋朱维莉时杰
Owner PEKING UNIV
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