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A method for rapidly preparing Euphorbia factor l1 from the fruit of Capperia spp.

A technology of euphorbia factor and scaper caper, which is applied in the direction of organic chemistry, etc., to achieve the effect of simple preparation process and easy operation

Active Publication Date: 2015-08-19
SICHUAN JISHENG BIOPHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There is no report on the rapid preparation of high-purity Euphorbia factor L1 from the fruit of Scaper chinensis

Method used

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  • A method for rapidly preparing Euphorbia factor l1 from the fruit of Capperia spp.
  • A method for rapidly preparing Euphorbia factor l1 from the fruit of Capperia spp.

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Take 2000g of caperia fruit, and use a conventional oil press to squeeze out the oil in the caperia fruit at room temperature;

[0027] (2) Dissolve the oil prepared above in 500ml of petroleum ether and transfer it to a separatory funnel, add 500ml of acetonitrile to the separatory funnel, shake, after the layers are separated, discard the acetonitrile layer, and use the same method to use acetonitrile Extract twice again to obtain petroleum ether extract;

[0028] (3) concentrating the petroleum ether extract under reduced pressure, recovering the petroleum ether, and obtaining an oily petroleum ether extract;

[0029] (4) Put the oily petroleum ether extract in a constant temperature bath at -5°C, and place it overnight. After a large amount of colorless crystals are precipitated, use vacuum filtration to obtain the crystals, and repeatedly wash the crystals with petroleum ether to remove the surface of the crystals. of fat;

[0030] (5) The washed colorless cr...

Embodiment 2

[0034] (1) Take 5000g of caperia fruit, and use a conventional oil press to squeeze out the oil in the caperia fruit at room temperature;

[0035] (2) Dissolve the oil prepared above in 1200ml of petroleum ether and transfer it to a separatory funnel, add 1200ml of acetonitrile to the separatory funnel, shake, and after the layers are separated, discard the acetonitrile layer, and use the same method to use acetonitrile Extract twice again to obtain petroleum ether extract;

[0036] (3) concentrating the petroleum ether extract under reduced pressure, recovering the petroleum ether, and obtaining an oily petroleum ether extract;

[0037] (4) Put the oily petroleum ether extract in a constant temperature tank at -15°C, and let it stand overnight. After a large amount of colorless crystals are precipitated, use vacuum filtration to obtain the crystals, and wash the crystals repeatedly with benzene to remove the impurities on the crystal surface. grease;

[0038] (5) The washed...

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Abstract

The invention discloses a method for rapidly preparing euphorbia factor L1 from euphorbia lathyris fruit. According to the invention, oil is pressed from euphorbia lathyris fruit, and is dissolved by using petroleum ether; the material is extracted by using acetonitrile; the obtained petroleum ether extract liquid is concentrated, such that a petroleum ether extract is obtained; the petroleum ether is subjected to standing under low temperature, such that the crystals of euphorbia factor L1 is precipitated; the crystals are obtained by pump filtration, and are washed by using an organic solvent; the crystals are dissolved by using an organic solvent; and re-crystallization is carried out, such that euphorbia factor L1 with a purity higher than 95% is obtained, wherein an yield can be higher than 0.2%.

Description

technical field [0001] The invention relates to a method for extracting and isolating euphorbia factor L1 from caperpins fruit. Background technique [0002] Euphorbia lathyris is a species of Euphorbia, distributed in more than 10 provinces and cities in my country, and is a traditional Chinese medicinal material. "Compendium of Materia Medica" and other records that the plant has the effects of "dispelling water to reduce swelling, breaking silt and killing insects". It has been reported in the literature that the active ingredients in this plant are mainly diterpenoids, especially the macrocyclic diterpenoids it contains have aroused extensive research interest. The results of pharmacological experiments show that the diterpenoids contained in Caper scapella plants have a variety of pharmacological activities, and are effective against liver cancer SMMC-7221, lung adenocarcinoma L 342 And gastric adenocarcinoma MCc80-3 has a strong inhibitory effect, in which euphorbia ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D303/32C07D301/32
Inventor 陈封政苟小军颜军郭晓强宋芹何钢刘嵬
Owner SICHUAN JISHENG BIOPHARM CO LTD
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