Method for treating breast cancer and ovarian cancer

A technology for ovarian cancer and breast cancer, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, inorganic active ingredients, etc., and can solve short-term problems

Inactive Publication Date: 2013-08-14
TAKEDA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Responses to these treatments may be transient, leading to persistent disease progression

Method used

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  • Method for treating breast cancer and ovarian cancer
  • Method for treating breast cancer and ovarian cancer
  • Method for treating breast cancer and ovarian cancer

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Embodiment Construction

[0013] 1. General description

[0014] The present invention relates to a method of preventing or treating certain cancers comprising administering to a patient in need thereof a therapeutically effective amount of a 17,20-lyase inhibitor.

[0015] The invention also relates to a method of preventing or treating certain breast or ovarian cancers comprising administering to a patient in need thereof a therapeutically effective amount of a 17,20-lyase inhibitor.

[0016] 2. Definition

[0017] As used herein, the term "cancer" refers to a cellular disorder characterized by uncontrolled or unregulated cell proliferation, decreased cell differentiation, an inappropriate ability to invade surrounding tissue, and / or the ability to establish new growth at ectopic sites . The term "cancer" includes, but is not limited to, solid tumors and hematogenous tumors. The term "cancer" encompasses diseases of the skin, tissues, organs, bone, cartilage, blood and blood vessels. The term "ca...

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Abstract

The present invention relates to a method for the prevention or treatment of certain breast cancers or ovarian cancer comprising administering to a patient in need thereof of a therapeutically effective amount of a 17,20-lyase inhibitor, wherein the breast cancer or ovarian cancer is estrogen receptor (ER) negative.

Description

technical field [0001] The present invention relates to a method of preventing or treating certain breast or ovarian cancers comprising administering to a patient in need thereof a therapeutically effective amount of a 17,20-lyase inhibitor. Background technique [0002] There are many similarities between prostate and breast cancers, both in underlying disease biology and in treatment approaches. Like prostate cancer, breast cancer is a steroid hormone-driven neoplastic disease (Jordan V.C. et al., Cancer Res. 2009, 69:1243-54; Folkerd E.J. (Folkerd, E.J. ) and Dowsett M. (Dowsett, M.), J. Clin. Oncol. 2010, 28: 4038-44), and it is estimated that 207,000 women in the United States alone in this year will be newly diagnosed with breast cancer and approximately 40,000 women will die from its disease ( www.cancer.gov / cancertopics / types / breast ; accessed 5 November 2010). When newly diagnosed, breast cancer is predominantly 'estrogen-dependent' (more than 70% of newly diagno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4188A61K33/243
CPCA61K31/675A61K31/513A61K31/138A61K31/704A61K31/7068A61K31/58A61K31/4188A61K33/24A61K31/5685A61K31/4196A61K31/517A61K45/06A61P15/00A61P35/00A61P43/00A61K33/243A61K2300/00
Inventor 詹姆斯·W·达尔诺瓦斯科
Owner TAKEDA PHARMA CO LTD
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