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Method and device for treating blood cholesterol disorders

A technology for cholesterol and total cholesterol, which can be used in blood diseases, extracellular fluid diseases, blood circulation treatment, etc., and can solve problems such as unsatisfactory results

Inactive Publication Date: 2013-09-18
GRIFOLS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such an effect may be undesirable, especially in patients with borderline and / or low HDL levels

Method used

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  • Method and device for treating blood cholesterol disorders
  • Method and device for treating blood cholesterol disorders
  • Method and device for treating blood cholesterol disorders

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Embodiment Construction

[0023] The apparatus used to remove low-density lipoprotein cholesterol (LDL) from whole blood is shown in figure 2 middle. The device may comprise a housing (1), an inlet (3) for receiving whole blood from a donor, means (2) for separating the plasma from the cellular components of the blood, and means for separating the cellular components of the blood into The device is divided back into the first outlet (4) (where the cellular components of the blood leave the device) and the second outlet (5) (where the plasma leaves the device). Preferably, said means for separating plasma from cellular components of blood is a centrifugal means (ie a centrifuge). More preferably, said means for separating plasma from cellular components of blood is a filtration means (ie, as used in double filtration plasmapheresis). The devices of the invention may be used in an extracorporeal method of lowering cholesterol as described herein. figure 1 is a schematic illustration of the in vitro s...

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PUM

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Abstract

The present invention refers to a device for treating cholesterol disorders for use in a method comprising administering at least one treatment regime including two or more rounds of plasmapheresis to a patient having abnormal total cholesterol, abnormal LDL levels and / or abnormal HDL levels prior to treatment. Treatment with said device results in decreased LDL levels in patients having abnormal LDL levels and increased HDL levels in patients having abnormal HDL levels. Each subsequent round of plasmapheresis is conducted weekly, but no more than twice per week.

Description

technical field [0001] The present invention relates to uses and devices for removing total cholesterol, low density lipoprotein cholesterol (LDL) and / or high density lipoprotein cholesterol (HDL) from whole blood. In particular, the device comprises means for separating red blood cells from plasma from said whole blood. Background technique [0002] Plasmapheresis is a common medical procedure used to separate plasma from whole blood. It has been used to treat patients with a variety of chronic diseases involving exchanges of 2.5 L or greater. Given the large volume, when plasmapheresis is used to treat a medical condition, once the plasma is separated from whole blood, the blood can be returned to the body along with replacement fluid such as fresh plasma and / or albumin solution. Plasmapheresis is also used to obtain human plasma donations. In these cases, the volume withdrawn is no greater than 880 mL, and the blood may be returned with or without replacement fluid. ...

Claims

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Application Information

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IPC IPC(8): A61M1/38A61K35/14A61K35/16
CPCA61M1/3496A61M1/3621A61M1/3693A61M1/38A61M2210/12A61M2205/75A61K35/16A61K35/14A61P3/00A61P3/06A61P7/00A61P7/08A61P9/00A61K45/06A61M1/34
Inventor 维克托·基立福卢卡斯维克托·基立福罗拉
Owner GRIFOLS
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