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Evidence-based method for screening gastric cancer prognosis molecular markers

A technology of molecular markers and screening methods, applied in the direction of electronic digital data processing, special data processing applications, instruments, etc., can solve the problems that affect the research and application process of gastric cancer prognostic biomarkers, knowledge accumulation and huge time consumption, etc., to achieve Improve the application value, reduce manpower and financial resources, and reduce the effect of professional threshold

Inactive Publication Date: 2013-09-18
ZHEJIANG UNIV
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AI Technical Summary

Problems solved by technology

Due to the above reasons, the accumulation of knowledge and time required by clinicians and enterprises to apply biomarkers will be huge, which greatly affects the research and application process of gastric cancer prognostic biomarkers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1. An evidence-based screening method for gastric cancer prognostic molecular markers, the following steps are performed in sequence:

[0035] 1. Formulate inclusion criteria for research evidence: (1) The research population is gastric cancer patients; (2) Evaluate the relationship between biomarkers and clinical effect indicators, and the clinical effect indicators must be overall survival (OS), progression-free survival ( One or more of PFS), chemotherapeutic drug sensitivity, recurrence, toxic side effects, clinicopathological features, etc.; (3) biomarkers include gene mutation, gene polymorphism, mRNA expression level, protein expression level, microRNA and One or several types of microsatellites; (4) provide clear biomarker detection methods; (5) the research design must be randomized controlled trials, cross-sectional studies, cohort studies or systematic reviews (meeting at least one of the above), divided For prospective research and retrospective r...

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Abstract

The invention discloses an evidence-based method for screening gastric cancer prognosis molecular markers. The method comprises the steps as follows: 1), an inclusion criterion is set for a gastric cancer prognosis biomarker experimental research; 2), a research evidence retrieval strategy is set; 3), the prognosis biomarkers are screened preliminarily; 4), research data are extracted; 5), quality assessment on the experimental research quality is performed; 6), standardized data are processed; 7), the prognosis biomarkers are screened; and 8), according to the screening criterion, the gastric cancer prognosis biomarkers having potential application values are screened, and the prognosis values are described. In conclusion, the evidence-based method for screening the gastric cancer prognosis biomarkers is provided, and the gastric cancer prognosis biomarkers are screened, so that the screening cost is reduced, the screening time is shortened, professional thresholds are reduced, and the application values of the prognosis biomarkers are increased.

Description

technical field [0001] The invention belongs to the field of biotechnology and relates to an evidence-based screening method for gastric cancer prognostic biomarkers. Background technique [0002] Gastric cancer is one of the most common malignant tumors of the digestive system, and its morbidity and mortality rank among the top among malignant tumors in my country and the world. According to the statistics of GLOBOCAN, in 2008, there were 989,000 new cases of gastric cancer in the world, and 463,000 cases in China, accounting for 46.8%. The death rate of gastric cancer is second only to lung cancer, with an annual death toll of about 737,000, 352,000 in China, accounting for 47.8%. In my country, the mortality rate of gastric cancer ranks third among malignant tumors, second only to lung cancer and liver cancer. The mortality rate is 24.71 / 100,000, accounting for 18.3% of all cancer deaths, of which the male mortality rate (32.46 / 100,000) is significantly higher For women ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/24
Inventor 余科张珊珊谭海清宓娅娜赵凌云
Owner ZHEJIANG UNIV
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