Anti-ccr4 antibody and its application

A technology of antibodies and antagonists, applied in the direction of antibodies, anti-inflammatory agents, anti-bacterial drugs, etc., can solve problems such as lack of applications
CN103328513BInactive Publication Date: 2016-04-27CANCER RES TECH LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CANCER RES TECH LTD
Publication Date
2016-04-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present disclosure provides epitopes that bind to the extracellular domain of human CC chemokine receptor 4 (CCR4) and are capable of inhibiting macrophage-derived chemokine (MDC) and / or thymus activation-regulated chemokine (TARC) Antibodies that bind to CCR4. The invention also provides immunoconjugates and compositions comprising such antibodies, as well as methods and uses involving such antibodies, particularly in the fields of medicine and diagnostics.
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Description

technical field

[0001] The present invention relates generally to antibodies, CCR4 biology and related therapeutic fields. More specifically, the invention provides antibodies that bind to CCR4. Such anti-CCR4 antibodies have applications in the diagnosis and treatment of diseases and conditions associated with CCR4, such as imaging tumor blood vessels, treating cancer and treating viral and other infections, and inflammatory and immune diseases. The antibody-based compositions and methods of the invention also extend to the use of immunoconjugates and other therapeutic compositions, kits and methods. Background technique

[0002] With more than 800 members, G protein-coupled receptors (GPCRs) represent the largest family of cell surface molecules involved in signaling and account for >2% of all genes encoded in the human genome. Members of the GPCR superfamily share a common membrane topology: an extracellular N-terminus, an intracellular C-terminus, and a seven-transm...

Claims

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