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Adhesive film for hypertrophic scar repair and preparation method thereof

A technology for hypertrophic scars and sticking films, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, peptide/protein components, etc., can solve the problems of unobserved curative effect, immaturity, and adverse consequences, and achieve easy tissue absorption, Improves stability and promotes absorption

Active Publication Date: 2015-10-14
HENAN HUIBO MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the treatment of hypertrophic scars at home and abroad mostly adopts local drug sealing, skin transplantation, surgical excision and skin grafting, compression therapy, crystal scar grinding, etc., which are not very mature in clinical practice, and the curative effect remains to be seen.
Moreover, some take a long time, suffer a lot, are easy to repeat, and have adverse consequences, etc. Many of them are not satisfactory

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0037] The preparation method of the above-mentioned sticking film comprises the following steps:

[0038] 1) Prepare gamma-interferon solution:

[0039] a. Get the γ-interferon of said weight portion, dilute it to the activity of γ-interferon with 0.5-1.0% PBS containing human blood albumin to be 0.3-0.6×10 8 IU / ml, sterilized and filtered for later use; PBS is phosphate buffer saline, used for molecular cloning and cell culture, pH=7.4, isotonic with human blood, the main components are potassium dihydrogen phosphate, disodium hydrogen phosphate, chloride sodium and potassium chloride;

[0040] 2) Prepare the liposome penetration enhancer of said parts by weight:

[0041] b. Dissolve the lecithin, sodium cholate and stearylamide in the proportions by weight in 80-400 parts of ethanol, and carry out rotary evaporation under reduced pressure at 28-33°C, with the speed controlled at 90-110rpm, until Ethanol evaporates completely;

[0042] 3) Encapsulating gamma-interferon ...

Embodiment 1

[0051] A patch for repairing hypertrophic scars, which includes a backing layer, a viscous polymer layer and an isolation layer bonded in sequence, the viscous polymer layer comprising viscous polymers, liposome penetration enhancers and Anti-scarring active ingredient.

[0052] The ratio by weight of the viscous polymer, liposome penetration enhancer and scar-removing active component is: 200 parts of viscous polymer, 100 parts of liposome penetration enhancer, 1 part of scar-removing active component, 500 parts of glycerin;

[0053] The liposome penetration enhancer comprises lecithin, sodium cholate and stearylamide, and the proportioning by weight of the lecithin, sodium cholate and stearylamide is: 60 parts of lecithin, 10 parts of sodium cholate, Stearamide 1 part.

[0054] The scar-removing active component includes γ-interferon, Va acid and Ve, and the weight ratio of the γ-interferon, Va acid and Ve is: 70 parts of γ-interferon, 1 part of Va acid, 5 parts of Ve sha...

Embodiment 2

[0070] A patch for repairing hypertrophic scars, which includes a backing layer, a viscous polymer layer and an isolation layer bonded in sequence, the viscous polymer layer comprising viscous polymers, liposome penetration enhancers and Anti-scarring active ingredient.

[0071] The ratio by weight of the viscous polymer, liposome penetration enhancer and scar-removing active component is: 550 parts of viscous polymer, 300 parts of liposome penetration enhancer, 10 parts of scar-removing active component, 8500 parts of glycerin;

[0072] The liposome penetration enhancer comprises lecithin, sodium cholate and stearylamide, and the proportioning by weight of the lecithin, sodium cholate and stearylamide is: 80 parts of lecithin, 20 parts of sodium cholate, Stearamide 7 parts.

[0073] The scar-removing active component includes γ-interferon, Va acid and Ve, and the weight ratio of the γ-interferon, Va acid and Ve is: 650 parts of γ-interferon, 12 parts of Va acid, 11 parts of...

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PUM

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Abstract

The invention discloses a film for hyperplastic scar repair and a preparation method thereof. The film comprises a back lining layer, a viscous polymer layer and an isolation layer which are sequentially bonded, wherein the viscous polymer layer comprises a viscous polymer, a liposome permeation promoter and a scar removal active component and can keep good adhesiveness and cohesiveness in the case of moisture or sweat; meanwhile, with good hydrophilcity and lipophicity, the viscous polymer layer is more favorable for the medicine to penetrate through skin to promote medicine absorption, and a higher medicine-through-skin rate can be obtained. The film for hyperplastic scar repair, disclosed by the invention, takes effect quickly, the course of treatment is short, and the hyperplastic scar does not recur easily. The preparation method is simple, and the process cost is low.

Description

technical field [0001] The invention relates to the technical field of scar repair, in particular to a patch for repairing hypertrophic scars and a preparation method thereof. Background technique [0002] Hypertrophic scars mostly occur after the wounds and deep burns have healed. The pathological difference between hypertrophic scars and normal scars lies in the thickening of collagen fibers in the deep part of the scar, which is irregularly arranged, or wavy, or entangled into ropes. Hypertrophic scars have been constantly changing since they occurred. At the beginning, the fibrous hyperplasia of the scar is very fast and numerous. After the fibrous hyperplasia is too much, the blood vessels inside the scar are often compressed, making it gradually ischemic. Flushing and congestion, firm and tough, with burning pain and itching. The common incision scar after the incision is sutured belongs to this kind. [0003] At present, the treatment of hypertrophic scars at home...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/21A61K9/70A61P17/02
Inventor 刘尧朱天钢李延浩
Owner HENAN HUIBO MEDICAL CO LTD
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