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Method for preparing caffeoylquinic acid

A technology of caffeoylquinic acid and toluene, which is applied in the field of preparing caffeoylquinic acid and can solve problems such as discussion on industrial separation

Inactive Publication Date: 2014-02-12
TAIZHOU XINWEI CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In fact, Artemisia annua contains not only artemisinin, but also caffeoylquinic acid (Jian Han, Min Ye, Xue Qiao, Man Xu, Bao-rong Wang, De-An Guo. Characterization of phenolic compounds in the Chinese herbal drug Artemisia annua by liquid chromatography coupled to electrospray ionization mass spectrometry. 2008, (47): 516-525), but this literature only identified caffeic acid quinic acid in the methanol extract class of substances, it was not quantified, nor was the extraction

Method used

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Examples

Experimental program
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Embodiment 1

[0012] Take 100g of the industrial extraction residue of Artemisia annua after extracting artemisinin with toluene, add it into the solution with pH=4.0, acetone:methanol=5:1 at a solid-to-liquid ratio of 1:70 (w / w), and immerse under microwave assistance. Extraction for 0.5 hours, countercurrent extraction for 4.5 hours, after solid-liquid separation, an extract containing caffeoylquinic acid was obtained. After liquid-liquid extraction and separation, 3.1 g of caffeoylquinic acid with a purity of 59% was obtained, and then separated and purified by chromatographic column 1.3 g of caffeoylquinic acid with a purity of 93% was obtained.

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Abstract

The invention relates to a method for preparing caffeoylquinic acid, which comprises the following steps of fetching 100g of artemisia annua industrial extraction remainder obtained after extracting artemisinin with toluene, and adding into a solution of which the pH is 4.0 and the acetone-methanol ratio is 5:1 according to a solid-liquid ratio of 1:70 (w / w); leaching for 0.5 hour under microwave assistance; performing counter-current extraction for 4.5 hours; performing solid-liquid separation to obtain extraction liquid containing caffeoylquinic acid; performing liquid-liquid extraction separation to obtain 3.1g of caffeoylquinic acid with purity of 59%; separating through a chromatographic column and purifying to obtain 1.3g of caffeoylquinic acid with purity of 93%.

Description

technical field [0001] The invention relates to a method for preparing caffeoylquinic acid. Background technique [0002] Artemisia annua is a plant of Compositae Artemisia annua L The dry aerial part of . has the effects of clearing heat, detoxifying, and antimalarial. Artemisinin is an active ingredient extracted from Artemisia annua, and it is the only new antimalarial drug internationally recognized in my country. [0003] Artemisia annua is rich in resources in my country, but the current industrial utilization of Artemisia annua is only a product of extracting artemisinin (Li Shiyu, Qi Xiangjuan, He Yujuan. Method for extracting and isolating artemisinin from Artemisia annua plants. CN200510015146.4). Other utilization of Artemisia annua resources mostly stays in Artemisia annua tea, compound granule (Xiao Wei, Wang Zhenzhong and Bi Yuan. A method for the content determination of Chinese patent medicine made from Artemisia annua, honeysuckle and gardenia. CN: 2010101...

Claims

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Application Information

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IPC IPC(8): C07C69/732C07C67/48
CPCC07C67/48
Inventor 苗陵生
Owner TAIZHOU XINWEI CHEM
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