Unlock instant, AI-driven research and patent intelligence for your innovation.

Ginkgo biloba total flavonoids double-layer osmotic pump controlled-release tablet and preparation method

A technology of osmotic pump controlled release and total flavonoids, which is applied in the direction of medical raw materials derived from Ginkgo biloba, pharmaceutical formulations, drug delivery, etc., can solve problems such as industrialization difficulties, cumbersome production processes, and increased production costs, so as to reduce side effects and maintain time. Long-lasting, less frequent medication effects

Inactive Publication Date: 2016-02-03
SHENYANG PHARMA UNIVERSITY
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the production process of the film is cumbersome, which increases the production cost and brings difficulties to industrialization.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ginkgo biloba total flavonoids double-layer osmotic pump controlled-release tablet and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Drug-containing layer composition:

[0060] Component content (mg / tablet)

[0061] Ginkgo biloba total flavonoids 200

[0062] NaCl 30

[0063] PEO-N1030

[0064] Magnesium Stearate 2

[0065] Booster layer composition: content (mg / tablet)

[0066] PEO-303100

[0067] NaCl 30

[0068] Magnesium Stearate 2

[0069] Coating solution composition: (1000ml coating solution)

[0070] Component weight

[0071] Cellulose acetate 30g

[0072] PEG40002g

[0073] water 5ml

[0074] Acetone 1000ml

[0075] The preparation method of the above-mentioned ginkgo leaf total flavonoids bilayer osmotic pump controlled-release tablet is as follows:

[0076] Prepare the drug-containing layer: weigh the total flavonoids of Ginkgo biloba leaves, suspending agent, osmotic pressure active substance, and lubricant according to the prescription and pass through an 80-mesh sieve, mix well, and set aside;

[0077] Prepare the booster layer: pass the polymer swelling agent, osmotic press...

Embodiment 2

[0081] Drug-containing layer composition:

[0082] Component content (mg / tablet)

[0083] Ginkgo biloba total flavonoids 220

[0084] Sucrose 15

[0085] PEO-N75022

[0086] Magnesium Stearate 5

[0087] Booster layer composition: content (mg / tablet)

[0088] PEON60K100

[0089] Sucrose 30

[0090] Magnesium Stearate 2

[0091] Coating solution composition: (1000ml coating solution)

[0092] Component weight

[0093] Ethyl cellulose 28g

[0094] PEG40001g

[0095] water 5ml

[0096] Acetone 1000ml

[0097] The preparation method of the above-mentioned ginkgo leaf total flavonoids bilayer osmotic pump controlled-release tablet is as follows:

[0098] Prepare the drug-containing layer: weigh the total flavonoids of Ginkgo biloba leaves, suspending agent, osmotic pressure active substance, and lubricant according to the prescription and pass through an 80-mesh sieve, mix well, and set aside;

[0099] Prepare the booster layer: pass the polymer swelling agent, osmoti...

Embodiment 3

[0103] Drug-containing layer composition:

[0104] Component content (mg / tablet)

[0105] Ginkgo biloba total flavonoids 200

[0106] Mannitol 30

[0107] Polyvinylpyrrolidone 20

[0108] Micropowder silica gel 2

[0109] Booster layer composition: content (mg / tablet)

[0110] PEO-303112

[0111] Sodium chloride 26

[0112] Micropowder silica gel 4

[0113] Coating solution composition: (1000ml coating solution)

[0114] Component weight

[0115] Cellulose acetate 30g

[0116] PEG40001g

[0117] water 5ml

[0118] Acetone 1000ml

[0119] The preparation method of the above-mentioned ginkgo leaf total flavonoids bilayer osmotic pump controlled-release tablet is as follows:

[0120] Prepare the drug-containing layer: weigh the total flavonoids of Ginkgo biloba leaves, suspending agent, osmotic pressure active substance, and lubricant according to the prescription and pass through an 80-mesh sieve, mix well, and set aside;

[0121] Prepare the booster layer: pass th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicine, and relates to a double-layer osmotic pump controlled-release tablet of ginkgo leaf total flavonoids and a preparation method. The double-layer osmotic pump controlled-release tablet is composed of three parts: a drug-containing layer, a booster layer and a coating film. The weight percentage of the drug-containing layer is composed of: 40%-90% of total flavonoids of Ginkgo biloba, 5%-35% of suspending agent, 5%-25% of osmotic pressure active substance, 0%-5% of lubricant; The weight percentage of the layer is composed of: polymer swelling agent 45% ~ 90%, osmotic pressure active substance 10% ~ 50%, lubricant 0% ~ 5%; the weight volume ratio of the coating film coating solution is composed of: high semipermeability Molecular material: 2% to 4%; porogen: 0.001% to 0.09%; solvent is a mixed solution of acetone: water = 1000:3 to 19; coating weight gain is 3% to 20% of the weight of the tablet core. The preparation has constant-speed drug release, is easy to control the blood drug concentration level, and reduces toxic and side effects. It can reduce the frequency of administration and improve the compliance of patients.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a double-layer osmotic pump controlled-release tablet of ginkgo leaf total flavonoids and a preparation method thereof. Background technique [0002] The total flavonoids of Ginkgo biloba is Ginkgo biloba extract, with a content of more than 20%. It mainly contains some flavonoids and flavonoid glycosides, including quercetin, isorhamnetin, and kaempferins. Pharmacological studies have shown that the total flavonoids of Ginkgo biloba can increase cerebrovascular flow, improve cerebrovascular circulation, protect brain cells, expand coronary arteries, prevent angina pectoris and myocardial infarction, prevent thrombosis, and improve the body's immunity. It is very beneficial to patients with coronary heart disease, angina pectoris, cerebral arteriosclerosis, senile dementia, and hypertension. [0003] At present, there are Chinese patent medicine preparation...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K36/16A61K9/22A61P9/10A61P25/28A61P9/12
Inventor 杨星钢潘卫三李江
Owner SHENYANG PHARMA UNIVERSITY