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Traditional Chinese medicine compound combination with function of curing chronic kidney diseases

A chronic kidney disease and composition technology, applied in the field of traditional Chinese medicine composition, can solve the problems of poor patient compliance, poor patient curative effect, long course of western medicine, etc., and achieve the effect of taking convenience, protecting kidney function, controlling and stabilizing the disease

Active Publication Date: 2014-03-26
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the methods used by Western medicine to treat chronic nephritis proteinuria include hormones, immunosuppressants, ACEI / ARB drugs, etc. Although some clinical curative effects have been achieved, there are still quite a few patients with poor curative effects, and the treatment course of Western medicine is long , easy to rebound after drug withdrawal, more side effects, poor patient compliance

Method used

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  • Traditional Chinese medicine compound combination with function of curing chronic kidney diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. A Chinese medicine compound composition for the treatment of chronic kidney disease, which is made from the following raw materials in parts by weight:

[0028] 20 parts of raw astragalus, 15 parts of Eucommia ulmoides, 10 parts of Ligustrum lucidum, 10 parts of golden cherry, 30 parts of Qingfengteng, 30 parts of stone reed, 15 parts of cat's claw, 20 parts of pangolin, 15 parts of silkworm, 5 parts of scorpion share.

[0029] 2. Add 12 times the amount of water to each component of the above 1, decoct and extract twice, 1 hour each time, combine the decoction, concentrate to a relative density of 1.12 (60°C heat test), add ethanol until the alcohol content reaches 60 %, stand still for 24 hours, filter, recover ethanol from the filtrate, continue to concentrate to a relative density of 1.30 (60°C heat test), add appropriate amount of starch, granulate, dry, and pack into capsules.

Embodiment 2

[0031] 1. A Chinese medicine compound composition for the treatment of chronic kidney disease, which is made from the following raw materials in parts by weight:

[0032] 60 parts of raw astragalus, 45 parts of Eucommia ulmoides, 30 parts of Ligustrum lucidum, 30 parts of golden cherry, 90 parts of Qingfengteng, 90 parts of stone reed, 45 parts of cat's claw, 60 parts of pangolin, 45 parts of silkworm, 15 parts of scorpion share.

[0033] 2. Add 8 times the amount of water to each component of the above 1, decoct and extract twice, 1 hour each time, combine the decoction, concentrate, cool to room temperature, add ethanol until the alcohol content reaches 65%, and let it stand for 24 hours , filtered, and ethanol was recovered from the filtrate to obtain an extract, which was dissolved in purified water, an appropriate amount of stevioside was added, the pH was adjusted to 5.5, subpackaged, and sterilized.

Embodiment 3

[0035] 1. A Chinese medicine compound composition for the treatment of chronic kidney disease, which is made from the following raw materials in parts by weight:

[0036] 40 parts of raw astragalus, 30 parts of Eucommia ulmoides, 20 parts of Ligustrum lucidum, 20 parts of golden cherry, 60 parts of Qingfengteng, 60 parts of stone reed, 30 parts of cat's claw, 40 parts of pangolin, 30 parts of silkworm, 10 parts of scorpion share.

[0037] 2. Add 10 times the amount of water to each component described in the above 1, decoct and extract 3 times, 1 hour each time, combine the decoction, filter, concentrate to a relative density of 1.10 (60°C thermal measurement), add ethanol When the alcohol content reaches 70%, stand still for 12 hours, filter, recover ethanol from the filtrate, concentrate to a thick paste, add appropriate amount of dextrin and aspartame, granulate, dry, granulate, and pack to obtain.

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Abstract

The invention discloses a traditional Chinese medicine compound combination with a function of curing chronic kidney diseases. The traditional Chinese medicine compound combination is prepared by 20-60 parts of astragali radix, 15-45 parts of eucommia ulmoides, 10-30 parts of glossy privet fruit, 10-30 parts of cherokee rose fruit, 30-90 parts of caulis sinomenii, 30-90 parts of herba pyrrosiae, 15-45 parts of radix ranunculi ternati, 20-60 parts of rhizoma dioscoreae nipponicae, 15-45 parts of stiff silkworms and 5-15 parts of scorpion. The invention further discloses a preparation method of the traditional Chinese medicine compound combination and an application of the traditional Chinese medicine compound combination in curing the curing chronic kidney diseases. The traditional Chinese medicine compound combination is obtained through long-time clinical application and screening under the guidance of the traditional Chinese medicine theory according to the pathogenesis of the chronic kidney diseases. Clinical test results show that the traditional Chinese medicine compound combination can remarkably reduce proteinuria, protect the kidney function and control and stabilize the illness condition of a patient suffering from chronic nephritis, the effective rate is up to 91.7%, no remarkable adverse reaction occurs in the test process, the application is safe, and the traditional Chinese medicine compound combination is hopeful to be developed into a new drug for curing proteinuria of chronic nephritis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine compound composition for treating chronic kidney disease and its application. Background technique [0002] Chronic kidney disease is a serious threat to human life and health, and its incidence is increasing year by year. It has become a global public health event and has attracted extensive attention from the medical community. Chronic nephritis is caused by a variety of reasons, with different pathological changes. It is clinically characterized by proteinuria, hematuria, edema, and high blood pressure. It is a group of diseases that originate in the glomeruli that are often accompanied by a slow decline in renal function as the disease progresses. TCM "kidney wind", "edema", "hematuria", "low back pain" category. Statistics show that chronic nephritis is still the primary cause of end-stage renal disease in my country. Once patients...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P13/12A61K35/64A61K35/646
Inventor 盛梅笑刘志辉李正红柳正伦
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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