Preparation process of isopropyl-β-d-thiogalactoside

Abstract

The invention relates to the field of sugar compounds, and concretely relates to an isopropyl-beta-D-thiogalactoside preparation technology. The technology comprises the following steps: adding acetic anhydride and a catalyst at room temperature, adding galactose, adding isopropyl mercaptan after the above reaction, and post-processing to obtain isopropyl thioacetylgalactosamine; and adding isopropyl thioacetylgalactosamine into methanol for dissolving, adding sodium methoxide, adding acetic acid after the above reaction to neutralize, and post-processing to obtain isopropyl-beta-D-thiogalactoside. The technology allows isopropyl-beta-D-thiogalactoside to be synthesized through a two-step reaction process, and has the advantages of simple operation, easily available raw materials, and saving of the operation cost and materials.

Description

technical field

[0001] The invention relates to the field of sugar compounds, in particular to a preparation process of isopropyl-β-D-thiogalactoside. Background technique

[0002] Isopropyl-β-D-thiogalactopyranoside, also known as IPTG, English name: Isopropyl β-D-1-Thiogalactopyranoside, CAS number: 367-93-1, molecular formula C 9 h 18 o 5 S.

[0003] In the prior art, the reaction of galactose and acetic anhydride under the action of sodium acetate is generally used to prepare pentaacetylgalactose, and the pentaacetylgalactose is dissolved in a catalyst and reacted with isopropyl mercaptan to prepare tetraacetylisopropylthiosemi Lactose and tetraacetylisopropylthiogalactose are deacetylated by sodium methoxide to prepare isopropyl-β-D-thiogalactoside. This method first prepares pentaacetylgalactose, and then purifies it to cause a certain consumption of raw materials. The operation is more complicated and the cost is higher. For example, patent: 201210553464, another...