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Serum/plasmanon miRNA marker for diagnosing non-small cell lung cancer at early stage and application thereof

A non-small cell lung cancer, early diagnosis technology, applied in the fields of genetic engineering and oncology, can solve the problems of loss of treatment time, increase of lung cancer mortality rate, lung cancer screening and diagnosis, etc., to achieve rapid direction, improve sensitivity and specificity, Easy to detect effects

Inactive Publication Date: 2014-04-16
CHANGSHA YINGRUN BIOTECH
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  • Description
  • Claims
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Problems solved by technology

The main reason for the increase in the mortality rate of lung cancer in my country is due to the lack of effective screening and diagnosis of lung cancer in the early stage, so 80% of lung cancer patients are already diagnosed at an advanced stage and have lost the best time for treatment

Method used

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  • Serum/plasmanon miRNA marker for diagnosing non-small cell lung cancer at early stage and application thereof
  • Serum/plasmanon miRNA marker for diagnosing non-small cell lung cancer at early stage and application thereof
  • Serum/plasmanon miRNA marker for diagnosing non-small cell lung cancer at early stage and application thereof

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Embodiment Construction

[0020] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0021] The use, method and kit of the present invention can be effectively used in the selection of tumor treatment plan and / or prognosis assessment, thereby providing a novel tumor diagnostic agent and / or therapeutic agent, which has a certain clinical application prospect. The specific implementation steps are as follows:

[0022] (1) Reaction system and conditions of Q-PCR

[0023]

[0024]

[0025] (2) Configuration of Q-PCR

[0026]

[0027] (3) Amplification ...

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Abstract

The invention belongs to the field of genetic engineering and oncology, and discloses a serum / plasmanon miRNA marker for diagnosing non-small cell lung cancer at an early stage and application thereof. The serum / plasmanon miRNA marker is any one of or combination of various of SEQ-1 miR-328, SEQ-2miR-339, SEQ-3miR-1254, SEQ-4 miR-574-5p, SEQ-5miR-21, and SEQ-6 miR-200C. The serum / plasmanon miRNA marker is a medicine used for preparing a diagnostic kit or curing the non-small cell lung cancer. The marker differs from the traditional biomarker, is not only stable, minimally invasive and easy to detect, but also is accurate in quantifying, and can greatly improve the sensibility and the specificity of disease diagnosis.

Description

technical field [0001] The invention relates to the fields of genetic engineering and oncology, in particular to a serum / plasma miRNA marker for early diagnosis of non-small cell lung cancer and its application. Background technique [0002] Lung cancer is one of the most common malignant tumors, and the mortality rate of lung cancer ranks first among malignant tumors worldwide. Lung cancer is one of the malignant tumors with the fastest increasing morbidity and mortality and the greatest threat to the health and life of the population. In the past 50 years, many countries have reported that the morbidity and mortality of lung cancer have increased significantly. The incidence and mortality of lung cancer in men rank first among all malignant tumors, and the incidence and mortality of lung cancer occupy the second place in women. The etiology of lung cancer is still not completely clear. A large number of data show that long-term heavy smoking has a very close relationship ...

Claims

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Application Information

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IPC IPC(8): C12Q1/68C12N15/11
CPCC12Q1/6886C12Q2600/178
Inventor 易银沙张万明曹蓬荣邹义洲李娜刘彩云袁炳秋吴小宁冯志明
Owner CHANGSHA YINGRUN BIOTECH
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