Novel application of coniferyl ferulate

Abstract

The invention relates to novel application of known compound coniferyl ferulate, and belongs to the technical field of medicines. Completed animal model tests indicate that the abnormal liver function of a CC14 induced mouse liver fibrosis model can be remarkably improved after coniferyl ferulate intervenes, the serum aspartate amino transferase and the level of serum total bilirubin can be reduced, the content of hydroxyproline can be reduced, the activation of hepatic stellate cells can be inhibited, type I collagen expression can be reduced, and collagen deposition of hepatic tissues can be inhibited.

Description

technical field [0001] The invention relates to a new application of a known compound and belongs to the technical field of medicine. Background technique [0002] Existing studies have shown that Coniferyl ferulate exists in Angelica, Chuanxiong and other Umbelliferae plants, and has antibacterial, anticancer and antioxidative effects. Liver fibrosis is a common pathological stage of various chronic liver diseases, including viral hepatitis, fatty liver disease, autoimmune liver disease, etc. HBV infection is highly prevalent in my country, with approximately 6.9 million infected persons. The incidence of alcoholic and non-alcoholic steatohepatitis is also increasing year by year. Most patients with chronic hepatitis are accompanied by liver fibrosis, and 12%-25% of them will progress to liver cirrhosis within 5 years. At present, most of the anti-hepatic fibrosis drugs are in the stage of experimental research, few of which are actually used in clinical practice, and ha...

AI Technical Summary

Problems solved by technology

At present, most of the anti-hepatic fibrosis drugs are in the experimental research stage, and few of them are actually used in clinical practice, and they have relatively large toxic and side effects

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