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Kit and gene chip for predicting nasopharynx cancer onset risk

A risk prediction, gene chip technology, applied in the determination/inspection of microorganisms, biochemical equipment and methods, etc., can solve the problems of low accuracy and reliability

Active Publication Date: 2014-04-30
WANSUI INVESTMENT HLDG (QINGDAO) CO LTD
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Problems solved by technology

However, this method is only for the detection of a very small number of indicators, and the accuracy rate is low; moreover, the reliability of this method needs to be verified by large-scale population samples

Method used

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  • Kit and gene chip for predicting nasopharynx cancer onset risk
  • Kit and gene chip for predicting nasopharynx cancer onset risk
  • Kit and gene chip for predicting nasopharynx cancer onset risk

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Embodiment Construction

[0017] (1) SNP loci significantly associated with the incidence of nasopharyngeal carcinoma for risk prediction of nasopharyngeal carcinoma

[0018] The present invention is a genome-wide association analysis of nasopharyngeal carcinoma based on a large-scale sample size of nasopharyngeal carcinoma population and normal control population, as well as a preliminary study on the screening results of susceptibility genes for nasopharyngeal carcinoma at the genome-wide level (A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci, Jin-Xin Bei et al, Nature Genetics, Volume 42, Number 7, 600-603, July 2010), and at the same time, the inventor used the statistical method of meta-analysis to analyze the The large-scale genome-wide association data were integrated and analyzed, and 1300 candidate SNP sites were obtained, and were compared in an independent Guangdong population cohort (2735 NPC patients and 3112 controls) and Guangxi populat...

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Abstract

The invention relates to a kit for predicting nasopharynx cancer onset risk, and a corresponding gene chip. The kit comprises a PCR (Polymerase Chain Reaction) amplification primer and a single base extension primer which are used for detecting 7 SNP (Single Nucleotide Polymorphism) loci of personal genome, wherein the 7 SNP loci are rs1412829, rs1572072, rs28421666, rs2860580, rs2894207, rs6774494 and rs9510787; the kit further comprises a PCR amplification primer and a single basic extension primer which are used for detecting 4 SNP loci of personal genome, wherein the 4 SNP loci are rs2853668, rs31489, rs402710 and rs4635969; the kit further comprises a nested PCR amplification primer for detecting a single nucleotide polymorphism locus G155391A with EB (Elzatein-Barn) virus subtype specificity related to nasopharynx cancer. The gene chip comprises upstream and downstream primers and probes for detecting 11 SNP loci of personal genome, and upstream and downstream primers and probes for detecting a single nucleotide polymorphism locus G155391A with the EB virus subtype specificity related to nasopharynx cancer, wherein the 11 SNP loci are rs1412829, rs1572072, rs28421666, rs2860580, rs2894207, rs6774494, rs9510787, rs2853668, rs31489, rs402710 and rs4635969.

Description

technical field [0001] The invention relates to a kit for predicting the risk of nasopharyngeal cancer and a corresponding gene chip, which are used for predicting the risk of nasopharyngeal cancer and screening high-risk groups of nasopharyngeal cancer to improve the early diagnosis rate of nasopharyngeal cancer. Background technique [0002] Nasopharyngeal carcinoma is a malignant tumor derived from the epithelium of the nasopharynx. It mainly occurs in the top of the nasopharynx and pharyngeal recesses. It is a complex disease affected by multiple factors. Its occurrence and development are closely related to genetic factors, EBV virus infection and environmental factors. China is a high-incidence area of ​​nasopharyngeal carcinoma in the world. According to the statistics of the World Health Organization, in 2008, new cases in China accounted for 39.2% (33,101 people) of the world, and deaths due to nasopharyngeal cancer accounted for 40.5% (20,899 people) of the world; a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCC12Q1/6886C12Q2600/156
Inventor 曾益新崔倩贾卫华贝锦新徐淼刘稳升
Owner WANSUI INVESTMENT HLDG (QINGDAO) CO LTD
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