Fructus alpiniae oxyphyllae and compatible lindera aggregata extract for treating diabetes, and preparation method thereof

Abstract

The invention discloses a fructus alpiniae oxyphyllae and compatible lindera aggregata extract for treating diabetes. The extract mainly comprises extract of petroleum ether part of fructus alpiniae oxyphyllae and compatible lindera aggregata extract, wherein the fructus alpiniae oxyphyllae and lindera aggregata are decocted with water according to the proportion of 1: 1 in a conventional way for three times, and concentrated solution is collected, so that dry extract can be obtained. The method comprises the steps of grinding, screening, carrying out reflux extraction, filtering, adding a solvent for extracting, recovering the solvent, carrying out ultrasonic extraction on lindera aggregata extract solution and preparing. According to the fructus alpiniae oxyphyllae and compatible lindera aggregata extract for treating the diabetes, and a preparation method of the extract provided by the invention, the harm of the diabetes to a patient is improved by the petroleum ether part of fructus alpiniae oxyphyllae extract, diabetic nephropathy (DN) can be treated by the extract, and kidney function decrease can be delayed; the fructus alpiniae oxyphyllae and compatible lindera aggregata extract is capable of promoting down regulation of the p27kip1 protein expression, has the functions of relieving kidney hypertrophia, reducing proteinuria and protecting the functions of the kidney, can effectively prevent diabetes complications, and is good in diabetes treatment effect.

Description

technical field [0001] The invention belongs to the technical field of plant extracts for treating nephropathy, and in particular relates to an extract of Yizhiren combined with black medicine for treating diabetes and a preparation method thereof. Background technique [0002] Diabetes belongs to the category of "diabetes" in traditional Chinese medicine, while kidney damage is mainly the development trend of DN. Diabetic nephropathy (DN) is mainly divided into 5 stages clinically. The onset of the first 3 stages is relatively hidden. Once it enters the 4th stage, it will appear Dominant protein indicates that the condition is already very serious, but currently there is no effective treatment. Increased cyclin kinase inhibitor P27 plays an important role in glomerular cell hypertrophy in diabetes mellitus (DM). Diabetic nephropathy (DN) is one of the most important vascular complications of diabetes and an important cause of death in diabetic patients. Most patients with ...

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Problems solved by technology

[0003] The purpose of the embodiments of the present invention is to provide a kind of Yizhiren compatible black medicine extract and its preparation method for the treatment of diabetes, aiming to solve the limitations of traditional plant extracts and methods for the treatment of diabetes, prevention of complications and The problem of poor treatment of diabetes

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