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New lactuside B purpose

A technology of lettucoside and medicine, which is applied in the field of new application of raptucoside B, can solve the problems that there are no reports on the antidepressant aspect of raptucoside B, and the specific mechanism is not clear, and achieve good application prospects, good water solubility, no Toxic effects

Active Publication Date: 2015-05-20
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have found that the depletion of serotonin and norepinephrine can easily induce emotional changes such as depression, anxiety, and fear, but the specific mechanism is still unclear
[0008] No report on antidepressant effect of Lactucoside B

Method used

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  • New lactuside B purpose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Therapeutic Effect of Lactucoside B on Depression in Mice

[0034] 1. Experimental animals: 80 male Kunming mice, weighing 20-22 g, were purchased from the Experimental Animal Center of Zhengzhou University.

[0035] 2. Experimental reagents and instruments:

[0036] Lactucoside B (prepared by Xinxiang Medical College School of Pharmacy, purity greater than 95%), fluoxetine hydrochloride (Eli Lilly Suzhou Pharmaceutical Co., Ltd.), swimming pool, Open·Field open box.

[0037] 3. Experimental grouping and experimental methods:

[0038] Before the experiment, 80 mice were adaptively fed for 1 week with 12 hours of light and 12 hours of no light, and then 10 mice were randomly selected as the normal control group: they were divided into two cages and raised in groups, with 5 mice in each cage. Feed and drinking water were given normally according to the needs, and no stimulation was accepted. The remaining mice were modeled according to the following method. ...

Embodiment 2

[0076] Example 2: Preventive effect of Lactucoside B on depression in mice

[0077] 1. Experimental animals: 50 male Kunming mice, weighing 20-22 g, were purchased from the Experimental Animal Center of Zhengzhou University.

[0078] 2. Experimental reagents and instruments:

[0079] Lactucoside B (prepared by Xinxiang Medical College School of Pharmacy, purity greater than 95%), fluoxetine hydrochloride (Eli Lilly Suzhou Pharmaceutical Co., Ltd.), swimming pool, Open·Field open box.

[0080] 3. Experimental grouping and experimental methods:

[0081] Before the experiment, 50 mice were adaptively fed for 1 week with 12 hours of light and 12 hours of no light, and then randomly selected 10 mice as the normal control group, 20 mice as the model group, and 20 mice as the lettucoside B prophylaxis group. The normal control group was divided into two cages and housed in groups, with 5 animals in each cage. Feed and drinking water were given normally according to the needs, and ...

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Abstract

The invention provides a new lactuside B purpose, and particularly relates to application in preparation of drugs for prevention and treatment of depressive disorder. The invention has the advantages that lactuside B has significant pharmacological effects which are mainly as follows: the lactuside B can increase body weight of mice subjected to the depressive disorder, increase the number of activities, prolong the swimming time of the mice subjected to the depressive disorder, reduce the immobility time in swimming, enhance sucrose preference degree of the mice subjected to the depressive disorder, and reduce the mortality of the mice subjected to the depressive disorder. The invention provides a new drug for prevention and treatment of the depressive disorder and brings the gospel to patients subjected to the depressive disorder.

Description

technical field [0001] The present invention relates to the new application of Lactucoside B, in particular to the application of Lactucoside B in the preparation of medicaments for preventing and treating depression. Background technique [0002] Pterocypsela elata (Hemsl.) Shih in Act. Also known as high lettuce Lactuca elata Hemsl. , which is a plant of the genus Pteraceae in the family Asteraceae, is distributed in more than a dozen provinces including Jilin, Gansu, and Henan in my country. It has the effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, and expelling wind. Lactuside B (lactuside B) is the main extract component of the root of tall lettuce, and its molecular formula is C 21 h 32 o 9 , the general structural formula is as follows: [0003] [0004] Among them, R is preferably Glc or H; R' is preferably CH 2 OH or CHO. [0005] It was early discovered that lettuceside B monomer has anti-cerebral ischemi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/365A61P25/24
Inventor 闫福林海广范李生莹郭兰青杨丽娟
Owner XINXIANG MEDICAL UNIV
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