39results about How to "Significant drug effect" patented technology

The present invention discloses a targeting anti-glioma protein, a preparation method and applications. The present invention separates out a protein, the sequence of which is an amino acid sequence shown as SEQ ID No: 1. Primers related to genetic engineering insert the nucleotide sequence of chlorotoxin into an expression vector pGEX-6p-1, so that a recombinant expression plasmid is formed; the recombinant expression plasmid transforms colon bacillus Rossetta (DE3), and after cell lysis, the Acp-W2 protein is produced by affinity chromatography, ultrafiltration, desalination and chromatography purification. The Acp-W2 protein has specific targeting effect on gliomas, can effectively inhibit the proliferation of rat gliomas and has targeting anti-glioma effect. The Acp-W2 protein is applicable to the preparation of drugs treating or preventing gliomas. The preparation method of the present invention has the advantages of simplicity, convenient operation, high output and good biological activity.

The invention discloses a genetic engineering immunity inhibiting peptide, a preparation method and application thereof. The invention separates a protein taking amino acid sequence shown in SEQ ID NO: 1 and SEQ ID NO: 1 as the sequence. The primer related to the genetic engineering inserts the ribonucleotide sequence of LWX-1 and LWX-AD-1 into a expression vector pGEX-6P-1 to constitute a recombinant expression plasmid; the recombinant plasmid transfers BL21(DE3), and then the cell splitting is subjected to GST affinity chromatography, enterokinase cutting and chromatogram purification to obtain LWX-1 and LWX-AD-1, and the molecule is respectively 4073.1Da and 4615.03Da through mass spectrum identification. LWX-1 and LWX-AD-1 protein can be applied to preparing medicines for curing or preventing target kalium channel Kv1.3, RRMS and rheumatic arthritis. The method is simple and easy to implement, and is convenient to operate.

The disclosed tablet is prepared from the following Chinese medicinal herbs including (by weight ratio), cape jasmine 10 parts, plantain seeds 10 parts, Chinese pink herb 10 parts, knotgrass 10 parts, talcum powder 10 parts, rhubarb horsetails 10 parts, clematis stem 10 parts, rush pith 5 parts, licorice root 10 parts, auxiliary materials 2 parts.

The invention relates to a medicament for treating verruca acuminate which is prepared from raw material herbs of globe thistle 15-38, borneol 1-5, brucea fruit 5-25 and licorice root 5-25. The medicament can be prepared into externally used liniment.

The invention belongs to technical field of medicines and relates to application of sitagliptin phosphate in preparation of a medicament for preventing and treating febrile convulsion. Currently, the sitagliptin phosphate has obvious medicament effect of clinically treating the febrile convulsion, but various serious side effects can be produced to damage children, and the tolerance and the addiction can be produced after long-time use. The product disclosed by the invention is definite in active ingredients, lower in cost and easy to implement.

The invention relates to a medication for treating thyroiditis, which is prepared by taking Chinese herbs as raw materials. The medication is prepared from southernwood, wizened scutellariae, cortex moutan, weeping forsythia, isatis root, ptunella vulgaris, picria fel-terrae, balloonflower root and zhebeinine and can be prepared into various common clinical medicine preparations. Proved by clinical test results, the medication has the advantages of definite effect, no toxic and side effect and safe and reliable clinical application.

The invention discloses a medicament for treating burn. The medicament is prepared from dragon's blood, Chinese angelica, kaolin, calamine, pearl, rhinoceros horn, frankincense, musk, myrrh, paris root, realgar, watermelon frost, prepared elephant hide, borax, dicatechin, borneol and gypsum rubrum which serve as raw materials. The medicament can be prepared into various medicines which are used clinically. In a formula, the medicaments are reasonable in compatibility, have the effects of clearing heat and detoxicating, inducing diuresis, relieving pain and stopping bleeding and promoting tissue regeneration under the synergetic treatment action, and are suitable for burn symptoms of different degrees. Clinical test results prove that the medicament has an obvious effect, does not have toxic or side effect, and is safe and reliable in clinical application.

The invention discloses a medicament for treating rheumatoid arthritis, which is prepared by using bixie sevenlobed yam rhizome, Fukuai, ginger, white atractylodes rhizome, Chinese ephedra, raw liquorice, rhizoma anemarrhenae, white paeony root, cassia twig, rhizoma alismatis and divaricate saposhnikovia root as raw materials. The medicament can be prepared into multiple preparations used clinically, and has better treatment effect on rheumatoid arthritis, no toxic and side effects and safe and reliable clinical application.

The invention relates to a drug for curing strumitis and a preparation method thereof. The drug takes traditional herbal medicine as raw materials to cure strumitis and is prepared by the traditional herbal medicine of sweet wormwood, scutellaria baicalensis georgi, cortex moutan, weeping forsythiae capsule, indigowoadRoot, common selfheal fruit-spike, figwort root, platycodon root and thunberg fritillary bulb, and can be prepared into various drugs in clinic common use. The drug has confirmed curative effect, no toxic or side effect, safety and reliably of clinic application, which is proved by clinic test results.

The invention discloses a medicament for treating pneumonia, which is prepared from the following raw materials: yam rhizome, aconite, ginger, atractylis ovata, herba ephedrae, raw liquorice root, rhizoma anemarrhenae, radix paeoniae alba, cassia twig, alisma orientale and hurricane lamp, the medicament can be prepared into multiple clinically used medicaments, and the medicament has good curative effect for pneumonia, no toxic or side effect as well as safe and reliable clinical application.

The invention discloses Tea for treating gastropathy, which is health care tea prepared by raw materials of angelica, fried atractylodes, bamboo shavings, tangerine peel, bulbus fritillaria, cynanchum glaucescens, radix codonopsis, Indian buead, anhydrous sodium sulphate, and corn; the medicament can be prepared into a medicament for external use in clinic; the invention has reasonable herb formulation for synergetic treatment, can course liver and regulate qi, harmonize stomach and relieve pain, is applicable to stomachache symptoms caused by hyperchlorhydria, poor appetite and the like in clinic. Clinical experiment results demonstrate that the medicament of the invention has obvious effect, no toxic or side effect, and is safe and reliable for clinical application.

The invention discloses an intestinal tract disease treatment patch, and concretely relates to the technical field of traditional Chinese medicines. The plaster-shaped patch is prepared through the steps of weighing 10-30g of longan pulp, 1-10g of Chinese prickly ash, 5-20g of American ginseng, 1-10g of moxa wool, 1-15g of Radix et Rhizoma Nardostachyos and a nonwoven fabric, mixing to form an excipient, and processing. The patch has the advantages of simple preparation method and reasonable formula, has the efficacies of liver coursing, qi rectifying, stomach harmonizing and pain relieving, is suitable for gastrointestinal discomfort caused by various excess stomach acid and poor appetite, has an obvious medicine effect and no toxic side effects, and is safe and reliable in clinic application.

The invention relates to a medicine for treating soft tissue pain, which is prepared by taking traditional Chinese medicines as raw materials. The medicine is prepared from the raw materials of speranskia tuberculata, acanthopanax bark, corydalis tuber, rhizoma sparganii, radix gentianae macrophyllae, erythrina bark, twotooth achyranthes root, logwood, psoralea corylifolia and the like and can be prepared into an externally-applied smearing medicament for use. The medicine has the effects of promoting blood circulation, eliminating blood stasis, decreasing swelling and alleviating pain, is locally applied, reaches a focus directly and has favorable conditioning and recovering functions. The medicine has a very good curative effect to the soft tissue pain and has no obvious side effect.

The invention discloses an application of scorpion source activity polypeptide BmKTX in preparing medicaments for curing or preventing rheumatoid arthritis. The scorpion source activity polypeptide BmKTX is produced and reconstructed by the gene project. The polypeptide medicament is characterized by: (1) strong particularity; the IC50 value of the scorpion source activity polypeptide BmKTX function medicament target potassium channel Kv1.3 is 102pM, and the scorpion source activity polypeptide BmKTX function medicament is the existing known polypeptide medicament with strong activity in the international world; (2) obvious medicament effect; the animal experiments prove that the recombination of the BmKTX polypeptide can cure rheumatoid arthritis of rats effectively; and (3) small toxic side effects; in animal experiments, the scorpion source activity polypeptide BmKTX does not cause obvious toxicity and side effects on experimental animals. The invention is simple and feasible in method and convenient in operation.

The invention relates to a new application of lettuce glucoside B, and particularly relates to an application of the lettuce glucoside B in preparation of medicines for prevention and treatment of kidney transplant. Experiments show that the lettuce glucoside B can be used for improving the renal function of rats subjected to kidney transplant and prolonging the survival time of the transplant kidney, the effects take on dosage dependency relationship, and the lettuce glucoside has a treatment effect on the transplant kidney.

The invention discloses a medicament for treating tracheitis, which is prepared from the following raw materials: trichosanthes kirilowii maxim, perilla fruit, white mustard seed, magnolia vine fruit, radish seed and red tangerine peel. The medicament can be prepared in multiple dosage forms for clinical application, has the efficacies of resolving heat, dissolving lumps, moistening the lung, resolving phlegm, warning the lung, supplementing qi, promoting production of body fluid, tonifying the kidney and calming the heart, has good curative effects on diseases such as tracheitis, bronchitis and the like, and is safe and reliable in clinical application.

The invention discloses a medicament for treating chronic erosive gastritis. The medicament is prepared from big fritillary, figwort root, poria, sliced finger citron, raw oyster, coix seed, zedoary, prepared liquoric root, fried bitter orange and raw white paeony root serving as raw materials. The medicament can be prepared into various medicaments for clinical use. Due to coordinative components and dialectical treatment, the medicament has the advantages of obvious clinical effect, no toxic or side effect and safe and reliable clinical application.

The present invention discloses a herbal extract for treating damp-toxin pains and a preparation method of the herbal extract. The herbal extract is characterized by being prepared from the followingraw materials in parts by weight: 50-100 parts of rosemary, 50-100 parts of radix et rhizoma rhodiolae crenulatae, 35-50 parts of safflowers, 20-30 parts of myrrh, 20-30 parts of frankincense, 50-80 parts of radix polygalae, 40-60 parts of herba gynostemmatis pentaphylli, 100-120 parts of magnetite, 200-300 parts of silkworm excrement, 200-250 parts of mulberry leaves, 100-150 parts of chrysanthemum, 100-200 parts of moxa floss, 30-50 parts of red paeony root, 25-35 parts of rhizoma chuanxiong, 100-150 parts of ginkgo leaves, 50-80 parts of kudzuvine root, 30-50 parts of drug sweetflag rhizome, 100-160 parts of polygonum multiflorum vine leaves, 35-50 parts of sharpleaf galangal fruits, 20-30 parts of spina date seeds, 100-200 parts of millet and 500-1,000 parts of a filler, water is addedinto the raw materials of the frankincense, radix polygalae, rhizoma chuanxiong, kudzuvine root and spina date seeds for decoction, filtering is conducted to remove dregs, the millet is added into the obtained filtrate, the filtrate is heated and concentrated into paste to wrap the millet and drying is conducted; and after the other medicines are crushed, the crushed medicines are mixed with themillet, and the mixture is loaded into a cloth bag to be sealed. The herbal extract is reasonable in the formula, improves sleep quality, strengthens the brain, benefits intelligence and promotes a memory function, and is suitable for children and primary and secondary school students to use.

The invention discloses a medicament for treating lumbocrural pains. The medicament is prepared from such raw materials as poria, arisaema cum bile, himalayan teasel root, eucommia bark, red peony root, Chinese tinospora stem, bidentate achyranthes root, Chinese angelica, red sage root, notopterygium root, erythrinae bard, radix stephaniae tetrandrae and asarum and can be prepared into various medicaments used clinically. The components of the medicament are reasonably compatible and are used for synergistically treating the lumbocrural pains. The medicament can be used for nourishing kidney, tonifying qi and dispelling coldness and warmth and is suitable for treating lumbocrural pain symptoms caused by fracture, dislocation, ligament strain, lumbar muscle strain and the like. Clinical trial results prove that the medicament has an obvious effect and no toxic or side effects and is safe and reliable to use clinically.

The invention discloses a heart-saving pill and in particular relates to a heart-saving gold pill and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The heart-saving gold pill is prepared from the following raw materials in parts by weight: 1.1 parts of musk, 2.5 parts of calculus bovis, 3.6 parts of venenum bufonis, 2.5 parts of pearl essence, 5 parts of pseudo-ginseng, 15 parts of cornu bubali concentrated powder, 5 parts of gall powder, 0.5 part of borneol, 10 parts of ginseng, 1.43 parts of rice flour, 12 parts of glutinous rice flour and 0.05-0.07 part of a gold foil. Compared with an existing disclosed heart-saving gold pill, the heart-saving gold pill takes the rice flour and glutinous rice flour as the raw materials which are matched with a small amount of gold foil, and is prepared by the preparation method. The heart-saving gold pill is remarkable in drug effect and free of side effect, and has the characteristics of being convenient to process, uniform in coating of the gold foil and small in dosage of the gold foil.

The invention discloses a process for continuously synthesizing prochloraz and an intermediate acylate of a prochloraz active compound, and relates to the technical field of pesticide chemical engineering. The prochloraz comprises the following raw materials in parts by weight: 100 parts of 2,4, 6-trichlorophenol, 70-90 parts of liquid alkali, 150-190 parts of dichloroethane, 2-5 parts of imidazole, 120-180 parts of propylamine, 25-50 parts of caustic soda flakes, 3-5 parts of an antioxidant, 2-3 parts of a catalyst, 3-5 parts of a stabilizer, 200-250 parts of toluene, 35-45 parts of triethylamine, 180-230 parts of an extraction agent and 120-150 parts of trichloromethyl carbonate. The amination reaction time is shortened, the amination reaction yield is improved, the reaction time is substantially shortened; the conversion rate of the raw materials reaches 98% or above, the yield of the product reaches up to 96%, the purity of the product is improved; the catalyst can be repeatedly used after being soaked in ethanol, the cost is saved; and the process is safe and environment-friendly, is greatly superior to the preparation process in the prior art and is very suitable for large-scale industrial production.

The invention discloses a traditional Chinese medicinal water decoction for treating gastrointestinal diseases, and concretely relates to the technical field of traditional Chinese medicines. The water decoction is prepared through the following steps: weighing 10-50g of cuttlefish bone, 5-20g of prepared Corydalis tuber, 5-15g of Radix Astragali, 25-50g of chicken's gizzard membrane, 1-15g of Polyporus Umbellatus, 10-30g of dark plum, 1-10g of Radix Curcumae Aromaticae, 1-10g of Rhizoma Cyperi, 1-6g of Alpinia officinarum Hance and 1-15g of Radix et Rhizoma Nardostachyos, mixing, crushing, sieving, adding water, decocting three times, filtering, uniformly mixing, and filtering. The traditional Chinese medicinal water decoction has very good conditioning and health care effects on stomach upset, aches, abdominal distension and gastric ulcer caused by various reasons, has no toxic side effects and has substantial curative effects.

The invention provides a new lactuside B purpose, and particularly relates to application in preparation of drugs for prevention and treatment of depressive disorder. The invention has the advantages that lactuside B has significant pharmacological effects which are mainly as follows: the lactuside B can increase body weight of mice subjected to the depressive disorder, increase the number of activities, prolong the swimming time of the mice subjected to the depressive disorder, reduce the immobility time in swimming, enhance sucrose preference degree of the mice subjected to the depressive disorder, and reduce the mortality of the mice subjected to the depressive disorder. The invention provides a new drug for prevention and treatment of the depressive disorder and brings the gospel to patients subjected to the depressive disorder.

The invention discloses an application of scorpion source activity polypeptide BmKTX in preparing medicaments for curing or preventing rheumatoid arthritis. The scorpion source activity polypeptide BmKTX is produced and reconstructed by the gene project. The polypeptide medicament is characterized by: (1) strong particularity; the IC50 value of the scorpion source activity polypeptide BmKTX function medicament target potassium channel Kv1.3 is 102pM, and the scorpion source activity polypeptide BmKTX function medicament is the existing known polypeptide medicament with strong activity in the international world; (2) obvious medicament effect; the animal experiments prove that the recombination of the BmKTX polypeptide can cure rheumatoid arthritis of rats effectively; and (3) small toxic side effects; in animal experiments, the scorpion source activity polypeptide BmKTX does not cause obvious toxicity and side effects on experimental animals. The invention is simple and feasible in method and convenient in operation.

The invention discloses a scorpion active polypeptide ADP-7 and an application thereof, belonging to the field of biotechnology. The scorpion active polypeptide designed in the present invention has the amino acid sequence shown in SEQ ID NO:1. The polypeptide has high selectivity and low toxicity as a potassium ion channel Kv1.3 blocker. The invention provides the application of the scorpion active polypeptide in medicine for treating or preventing diseases related to potassium channel Kv1.3.

The invention discloses a genetic engineering immunity inhibiting peptide, a preparation method and application thereof. The invention separates a protein taking amino acid sequence shown in SEQ ID NO: 1 and SEQ ID NO: 1 as the sequence. The primer related to the genetic engineering inserts the ribonucleotide sequence of LWX-1 and LWX-AD-1 into a expression vector pGEX-6P-1 to constitute a recombinant expression plasmid; the recombinant plasmid transfers BL21(DE3), and then the cell splitting is subjected to GST affinity chromatography, enterokinase cutting and chromatogram purification to obtain LWX-1 and LWX-AD-1, and the molecule is respectively 4073.1Da and 4615.03Da through mass spectrum identification. LWX-1 and LWX-AD-1 protein can be applied to preparing medicines for curing or preventing target kalium channel Kv1.3, RRMS and rheumatic arthritis. The method is simple and easy to implement, and is convenient to operate.

According to the application of the neferine in preparation of the anti-hepatitis B virus medicine, the neferine targets hepatitis B virus RNA and interferes with synthesis of the hepatitis B virus RNA, so that transcription of pgRNA, preS / S RNA and X RNA of the virus is reduced, reverse transcription synthesis of cDNA in a virus nucleocapsid in a cell and synthesis of virus protein are reduced, and therefore, the anti-hepatitis B virus medicine is obtained. Therefore, the synthesis and secretion of antigens HBsAg and HBeAg are reduced. According to the application disclosed by the invention, an in-vitro cell model is applied, the neferine is found to have an inhibiting effect on the HBV for the first time, and a new clue is provided for subsequent in-depth research and clinical medication of resisting the HBV.

The invention belongs to technical field of medicines and relates to application of sitagliptin phosphate in preparation of a medicament for preventing and treating febrile convulsion. Currently, the sitagliptin phosphate has obvious medicament effect of clinically treating the febrile convulsion, but various serious side effects can be produced to damage children, and the tolerance and the addiction can be produced after long-time use. The product disclosed by the invention is definite in active ingredients, lower in cost and easy to implement.

The invention discloses a medicament for treating apoplexia. The medicament is prepared by taking monkshood, ginseng, asarum, the root of bidentate achyranthes, lumbricus and liquorice as raw materials. The medicament disclosed by the invention can be prepared into a plurality of agents for clinical use. The medicament disclosed by the invention has a good curative effect on diseases, such as apoplexia, and has the advantages of being free from toxic and side effects, obvious in effect, and safe and reliable for clinical use.

The invention discloses an application of porcellio scaber latreille in preparation of medicines for treating diseases and symptoms of hyperthermia. Experimental research results indicate that the porcellio scaber latreille has significant antipyretic effect, can significantly inhibit rat fervescence induced by lipopolysaccharide, maintains in a relatively small temperature fluctuation range, andhas obvious effects on treatment of cold fever in children and cooling of fever in adults as well as alleviation of headache symptoms; porcellio scaber latreille is confirmed to be used for preparingmedicines for treating the diseases and symptoms of hyperthermia caused by cold or infections of bacteria, viruses and other pathogenic microorganisms or other diseases.