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Application of sitagliptin phosphate in preparation of medicament for preventing and treating febrile convulsion

A technology for the prevention and treatment of sitagliptin phosphate, which is applied in the field of medicine, can solve the problems of no sitagliptin phosphate, etc., and achieve the effect of easy implementation, low cost, and clear active ingredients

Inactive Publication Date: 2013-04-24
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are currently no reports on the application of sitagliptin phosphate in the treatment of febrile convulsions

Method used

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  • Application of sitagliptin phosphate in preparation of medicament for preventing and treating febrile convulsion
  • Application of sitagliptin phosphate in preparation of medicament for preventing and treating febrile convulsion
  • Application of sitagliptin phosphate in preparation of medicament for preventing and treating febrile convulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Inhibition of Sitagliptin Phosphate to Febrile Convulsion Disease

[0031] (1) Localization experiment of lateral ventricle and hippocampus in rats: 30 15-day-old SD rats were randomly divided into two groups, the normal saline group and the experimental group, and localization of the lateral ventricle and hippocampus was carried out. The rats were fixed on a stereotaxic instrument, disinfected with 75% alcohol, and the scalp was cut along the midline of the top of the head. Referring to the Paxinos and Watson mouse brain atlas, with the help of a stereotaxic instrument, drill a hole with a miniature electric cranial drill, insert a stainless steel guide tube with an outer diameter of 0.5 mm into the right ventricle (AP: 1.5 mm, R: 1.5 mm, H: 3.5 mm ), and at the same time insert the electrodes into the hippocampus on both sides of the brain (2.5mm, 2.5mm, 2.5mm), and fix them on the surface of the skull with dental cement.

[0032] (2) Drug injection exper...

Embodiment 2

[0038] Example 2 Test of Sitagliptin Phosphate on Learning and Memory Function and Spatial Cognitive Function of Rats

[0039] (1) Select 60 (male) 15-day-old SPF SD rats and randomly divide them into 3 groups (20 rats in each group) experimental (sitagliptin phosphate inhibitor) group, normal saline group, and normal group. The learning and memory function and spatial cognition function of the experimental group, normal saline group and normal group were detected by Morris water maze method. The experimental water tank is a galvanized circular tank with a diameter of 150 cm and a height of 50 cm. The water depth in the pool is 25 cm, and the water temperature is 22-23 °C. Add ink to the water to make the pool opaque. The pool is divided into four quadrants, and a platform with a height of 23.5 cm and a diameter of 8 cm is placed at a distance of 25 cm from the edge of a certain quadrant, hidden 1.5 cm below the water surface.

[0040] The experiment is divided into two par...

Embodiment 3

[0046] Example 3 Nissl staining to detect neuron state experiment

[0047] Nissl bodies are an indicator to reflect the state of neurons: under normal physiological conditions, Nissl bodies are large and numerous, reflecting the strong function of nerve cells to synthesize proteins. When neurons are damaged, the number of Nissl bodies can be reduced or even disappear.

[0048] The experimental steps are as follows:

[0049] (1) Tissue slices: Rats in the experimental group, normal saline group, and normal group were perfused immediately after the EEG experiment. After intraperitoneal injection of pentobarbital (400mg / kg) for anesthesia, the left ventricle was perfused and fixed with 4% paraformaldehyde according to the conventional method, and the brain was taken out. Specific method: fix the rat supine on the dissecting board, open the chest under the xiphoid process to expose the heart, find the apex of the heart, insert a blunt puncture needle through the left ventricle...

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Abstract

The invention belongs to technical field of medicines and relates to application of sitagliptin phosphate in preparation of a medicament for preventing and treating febrile convulsion. Currently, the sitagliptin phosphate has obvious medicament effect of clinically treating the febrile convulsion, but various serious side effects can be produced to damage children, and the tolerance and the addiction can be produced after long-time use. The product disclosed by the invention is definite in active ingredients, lower in cost and easy to implement.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the application of a compound sitagliptin phosphate in the preparation of drugs for preventing and treating febrile convulsions. Background technique [0002] Febrile convulsions are the most common emergency symptoms of central nervous system dysfunction in childhood, especially in infants and young children, with a total incidence of about 2% to 4%, 2% to 5% in Europe and the United States, and 6% in Japan ~9%, and even as high as 14% in some areas. Febrile convulsions can lead to neurological sequelae. Retrospective studies have shown that 40% of patients with a history of complex febrile convulsions will develop hippocampal sclerosis and temporal lobe epilepsy. At the same time, epidemiological surveys have shown the relative risk of epilepsy in children Sex is 10 times that of ordinary children. Therefore, the prevention and treatment of febrile convulsion disease is extrem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4985A61P25/08
Inventor 何小华刘万红彭碧文徐健范元腾李亮
Owner WUHAN UNIV
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