Application of porcellio scaber latreille in preparation of medicines for treating diseases and symptoms of hyperthermia

A technology of sputum and body temperature, which is applied to the application field of sagebrush in the preparation of medicines for treating diseases and symptoms related to hyperthermia, and achieves the effects of simple and feasible preparation process, significant antipyretic effect, and inhibition of body temperature rise.

Inactive Publication Date: 2018-12-14
GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been reported so far that it is used as a medicine for the preparation of diseases related to hyperthermia

Method used

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  • Application of porcellio scaber latreille in preparation of medicines for treating diseases and symptoms of hyperthermia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: The antipyretic effect of chrysalis on lipopolysaccharide-induced fever rats.

[0020] 1. The preparation of the herbal medicinal material:

[0021] Use low heat to dry the mouse woman, and grind it into powder. Ratwort powder was directly mixed with normal saline, and ultrasonically treated for 15 minutes.

[0022] 2. Antipyretic experiment:

[0023] 60 qualified SD male rats were selected and randomly divided into 6 groups (blank control group, model group, positive control group, high-dose treatment group, medium-dose treatment group, and low-dose treatment group) in each group 10 only. The control group was administered with normal saline, the positive control group was administered with ibuprofen suspension (dose 1ml / (kg. times)), the experimental group was administered with Ratwo suspension, the high dose group was 0.2g / kg, the middle dose was 0.2g / kg. Group 0.1 g / kg, low dose group 0.05 g / kg. Male SD rats were fed at room temperature for three day...

Embodiment 2

[0030] Example 2: Observation on the clinical efficacy of Shufu in treating children with cold and fever.

[0031] Children's thermoregulatory center is immature, and their ability to regulate body temperature is limited. It is easy to cause benign febrile convulsions, epileptic seizures, tachycardia and many other discomforts. brain damage. In the rat woman treatment group, 90% of these patients' fever symptoms returned to normal body temperature in a relatively short period of time.

[0032] Survey data: number of patients treated: 100, age: 2-15 years old, of which: 20 people aged 2-6 years old, 55 people aged 6-10 years old, 25 people aged 10-15 years old. 65 people took it once, and 35 people took it twice. The effective number of people is 92, and the effect is not obvious for 8 people.

[0033] Case report: Cheng X, 12 years old, had a fever due to a cold, and his body temperature reached 39.0°C. He dried 2 pieces of ratwort. After 4 hours, his body temperature retur...

Embodiment 3

[0034] Example 3: Observation of the clinical efficacy of Shufu in treating adults with cold and fever.

[0035] Survey data: Number of people treated: 30 people, age: 18-40 years old, of which: 15 people aged 18-25 years old, 10 people aged 26-35 years old, 5 people aged 36-40 years old. 25 people took it once, and 5 people took it twice. The effective number of people is 27, and the effect is not obvious for 3 people.

[0036] Case report: Liu ××, 25 years old, had a fever due to a cold, and his body temperature reached 39.4°C. He dried 4 pieces of ratwort. After 4 hours, his body temperature returned to normal, and his headache and other symptoms were alleviated.

[0037] In practical application, murine can be used as a single component, combined with one or more pharmaceutically acceptable carriers or excipients to make a pharmaceutical composition (single prescription), which is used to treat colds caused by colds or caused by bacteria, viruses, etc. Diseases and sympt...

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PUM

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Abstract

The invention discloses an application of porcellio scaber latreille in preparation of medicines for treating diseases and symptoms of hyperthermia. Experimental research results indicate that the porcellio scaber latreille has significant antipyretic effect, can significantly inhibit rat fervescence induced by lipopolysaccharide, maintains in a relatively small temperature fluctuation range, andhas obvious effects on treatment of cold fever in children and cooling of fever in adults as well as alleviation of headache symptoms; porcellio scaber latreille is confirmed to be used for preparingmedicines for treating the diseases and symptoms of hyperthermia caused by cold or infections of bacteria, viruses and other pathogenic microorganisms or other diseases.

Description

technical field [0001] The invention relates to a new medical application of saffron, in particular to the application of sputum in the preparation of medicines for treating diseases and symptoms related to hyperthermia. Background technique [0002] Hyperthermia refers to the rise of body temperature beyond the normal range due to the upward shift of the set point of the thermoregulatory center due to various reasons. Hyperthermia: Clinically also known as fever or fever, it refers to any reason that causes excessive heat production, reduced heat dissipation, thermoregulation disorders, and pyrogens acting on the thermoregulatory center to move the regulatory point upwards. Normal range, called elevated body temperature. Generally speaking, when the armpit temperature exceeds 37°C or the oral temperature exceeds 37.5°C, and the body temperature fluctuates by more than 1°C throughout the day and night, it can be called hyperthermia. [0003] Fever is a clinical manifestati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/63A61P29/00A61P11/00A61P31/04A61P31/12
CPCA61K35/63A61P11/00A61P29/00A61P31/04A61P31/12
Inventor 李军刘晓清
Owner GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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