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Heat-clearing antipyretic coating agent for pigs and preparation method of heat-clearing antipyretic coating agent

A film coating agent and solvent technology, applied in the field of veterinary medicine, can solve problems such as increasing stress, and achieve the effects of long-lasting curative effect, low stress and good film-forming properties

Active Publication Date: 2014-05-28
江苏欧克动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The conventional method of clearing away heat and relieving pain is to inject analgin or aminopyrine and other injections. The injections need to be caught, immobilized and injected for 3 to 5 consecutive days, which will undoubtedly increase the stress on the patient.

Method used

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  • Heat-clearing antipyretic coating agent for pigs and preparation method of heat-clearing antipyretic coating agent
  • Heat-clearing antipyretic coating agent for pigs and preparation method of heat-clearing antipyretic coating agent
  • Heat-clearing antipyretic coating agent for pigs and preparation method of heat-clearing antipyretic coating agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A coating agent for clearing heat and reducing fever of pigs, which comprises the following components:

[0026] Nimesulide 80g / L, Bupleurum volatile oil 50ml / L, ethyl cellulose 20g / L, L-menthol 20g / L, povidone k-3020g / L, triacetin 5g / L, ethanolamine 40 ml / L, solvent is ethanol.

[0027] The preparation method of the above-mentioned coating agent for clearing away heat and reducing fever of pigs, it comprises the following steps:

[0028] (1) Prepare liquid A: Add 20 grams of ethyl cellulose, 20 grams of povidone k-3020 and 5 grams of glycerol triacetate into 400 ml of absolute ethanol, and dissolve in a water bath at 45°C to obtain liquid A;

[0029] (2) Preparation of liquid B: Weigh 80 grams of nimesulide, add 400 ml of absolute ethanol and stir to mix, add 50 ml of bupleurum volatile oil, stir and mix well, then add 40 ml of ethanolamine, stir until dissolved, then add 20 grams of L-menthol, stirred until dissolved to obtain liquid B;

[0030] (3) Slowly add li...

Embodiment 2

[0033] A coating agent for clearing heat and reducing fever of pigs, which comprises the following components:

[0034] Nimesulide 60g / L, Bupleurum volatile oil 40ml / L, ethyl cellulose 15g / L, L-menthol 18g / L, Povidone K-30 15g / L, triacetin 5g / L, ethanolamine 40 ml / L, solvent is ethanol.

[0035] The preparation method of the above-mentioned coating agent for clearing away heat and reducing fever of pigs, it comprises the following steps:

[0036] (1) Preparation of liquid A: Add 15 grams of ethyl cellulose, 15 grams of povidone k-3015 and 5 grams of glycerol triacetate into 400 ml of absolute ethanol, and dissolve in a water bath at 45°C to obtain liquid A;

[0037] (2) Preparation of liquid B: Weigh 60 grams of nimesulide, add 400 ml of absolute ethanol, stir and mix, add 40 ml of bupleurum volatile oil, stir and mix well, then add 40 ml of ethanolamine, stir until dissolved, then add 18 grams of L-menthol, stirred until dissolved, to obtain liquid B;

[0038] (3) Slowly...

Embodiment 3

[0041] A coating agent for clearing heat and reducing fever of pigs, which comprises the following components:

[0042] Nimesulide 90g / L, Bupleurum volatile oil 60ml / L, ethyl cellulose 25g / L, L-menthol 22g / L, Povidone K-3025g / L, triacetin 5g / L, ethanolamine 40 ml / L, solvent is ethanol.

[0043] The preparation method of the above-mentioned coating agent for clearing away heat and reducing fever of pigs, it comprises the following steps:

[0044] (1) Preparation of liquid A: Add 25 grams of ethyl cellulose, 25 grams of povidone k-3025 and 5 grams of glycerol triacetate into 400 ml of absolute ethanol, and dissolve in a water bath at 45°C to obtain liquid A;

[0045] (2) Preparation of liquid B: Weigh 90 grams of nimesulide, add 400 ml of absolute ethanol, stir and mix, add 50 ml of bupleurum volatile oil, stir and mix well, then add 40 ml of ethanolamine, stir until dissolved, then add 22 grams of L-menthol, stirred until dissolved to obtain liquid B;

[0046] (3) Slowly add...

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Abstract

The invention discloses a heat-clearing antipyretic coating agent for pigs. The heat-clearing antipyretic coating agent comprises the following components: 60-90 g / L nimesulide, 40-60 ml / L radix bupleuri volatile oil, 15-25 g / L ethyl cellulose, 18-22 g / L L-menthol, 15-25 g / L povidone k-30, 5 g / L glyceryl triacetate, 40 ml / L ethanolamine, and alcohol used as a solvent. The invention further discloses the preparation method and application of the heat-clearing antipyretic coating agent. The heat-clearing antipyretic coating agent is good in film-forming property, can slowly release anthelmintic, realizes a quick antipyretic effect, and is long in curative effect and small in stress. The formula and the preparation method of the coating agent are unique, and the curative effect is obvious; a protective film can be formed, medicine on the inner side of the film can be permeated and absorbed, and the outer side of the film plays a protective role; the coating agent can not drop off automatically, and has incomparable advantages compared with water-based liniments and oil pouring agents.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a coating agent for clearing away heat and reducing fever of pigs through a skin administration route and a preparation method thereof. Background technique [0002] In fact, transdermal preparations have long been a widely used product. In my country, various preparations of traditional Chinese medicine are mainly used and are widely used. "Huangdi Neijing" records methods of external treatment of traditional Chinese medicine such as soaking, hot ironing, and smoking. "Synopsis of the Golden Chamber" created many methods and dosage forms of external treatment of medicines. Ointments, ointments, tablets, and liquids commonly used in milk are often used to treat colds, headaches, palpitations, asthma and other diseases. Since the Song Dynasty, there have been more than 40 methods of external treatment with medicines such as smearing, rubbing, wiping, apply...

Claims

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Application Information

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IPC IPC(8): A61K36/233A61K9/70A61K47/38A61P29/00A61K31/18
Inventor 戴鼎震方光远蒋加进孙静静王佳陈俊红仇明生
Owner 江苏欧克动物药业有限公司
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