A kind of sustained-release injection emulsion for treating bovine copper deficiency and preparation method thereof

A technology of deficiency and emulsion, applied in the field of sustained-release injection emulsion for treating bovine copper deficiency and its preparation field, can solve problems such as poor palatability, and achieve the effects of reducing release speed, increasing stability and prolonging action time.

Active Publication Date: 2016-03-30
NANNING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a slow-release injection medicine for the treatment of copper deficiency in cattle, to solve the problem of poor palatability of the above-mentioned supplementary copper source, and another purpose is to provide a method for preparing the slow-release injection medicine, which is simple and easy operate

Method used

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  • A kind of sustained-release injection emulsion for treating bovine copper deficiency and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The sustained-release injection emulsion for the treatment of bovine copper deficiency mainly includes the raw materials of the following weight components:

[0021] Copper glycinate powder 5g, glycerin 18g, liquid paraffin 43g, Tween 802g, Span 805g, aluminum stearate 1g, B vitamins 1g, vitamin D1g, vitamin E1g, vitamin C1g, diphenethylpiperidine 0.1g and sedative 0.2 g.

[0022] Prepared by the following method:

[0023] 1) Preparation of the water phase: First, stir Tween 80, B vitamins and vitamin C at high speed for 5 minutes to prepare liquid A; then grind the raw organic copper powder, pass through a 100-mesh sieve, weigh 5g, and dissolve in Prepare liquid B in 50 mL of 30% glycerin; mix liquid A and liquid B, and sterilize at 80°C and 1 MPa for 60 minutes to obtain the aqueous phase;

[0024] 2) Preparation of oil phase: Mix liquid paraffin, Span 80, vitamin D and vitamin E, and stir at high speed for 5 minutes, then add co-emulsifier, dissolve evenly, and the...

Embodiment 2

[0027] The sustained-release injection emulsion for the treatment of bovine copper deficiency mainly includes the raw materials of the following weight components:

[0028] Copper citrate powder 8g, glycerin 30g, liquid paraffin 50g, Tween 803g, Siban 808g, aluminum stearate 2g, B vitamins 1.5g, vitamin D1.5g, vitamin E1.5g, vitamin C1.5g, benzene Ethylpiperidine 1g and sedative 0.8g.

[0029] Prepared by the following method:

[0030] 1) Preparation of the water phase: First, stir Tween 80, B vitamins and vitamin C at high speed for 8 minutes to prepare liquid A; then grind the raw organic copper powder, pass through a 100-mesh sieve, weigh 8g, dissolve in Prepare liquid B in 80mL of 30% glycerin; mix liquid A and liquid B, and sterilize at 100°C and 3Mpa for 40min to obtain the aqueous phase;

[0031] 2) Preparation of oil phase: Mix liquid paraffin, Span 80, vitamin D and vitamin E, and stir at high speed for 8 minutes, then add co-emulsifier, dissolve evenly, and then st...

Embodiment 3

[0034] The sustained-release injection emulsion for the treatment of bovine copper deficiency mainly includes the raw materials of the following weight components:

[0035] Copper phenylalanine powder 10g, glycerin 37g, liquid paraffin 86g, Tween 805g, Span 8010g, monoglyceride stearate 3g, B vitamins 2g, vitamin D2g, vitamin E2g, vitamin C2g, phenethylpiperidine 2g and sedative 1g.

[0036] Prepared by the following method:

[0037] 4) Preparation of the water phase: First, stir Tween 80, B vitamins and vitamin C at high speed for 10 minutes to prepare liquid A; then grind the raw organic copper powder, pass through a 100-mesh sieve, weigh 10 g, dissolve in Prepare liquid B in 100mL of 30% glycerin; mix liquid A and liquid B, and sterilize at 121°C and 5Mpa for 20 minutes to obtain the aqueous phase;

[0038] 5) Preparation of oil phase: Mix liquid paraffin, Span 80, vitamin D and vitamin E, and stir at high speed for 10 minutes, then add co-emulsifier, dissolve evenly, and...

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Abstract

The invention discloses a slow-release injection emulsion for treating bovine copper deficiency, which is characterized in that it is mainly made of the following raw materials by weight: organic copper powder 5-10, glycerin 18-37, liquid paraffin 43 -86, Tween 802-5, Span 805-10, co-emulsifier 1-3. And by first preparing the water phase and the oil phase, and then preparing the required injection emulsion in one step. The injection obtained in the present invention is an emulsion, and the copper is coated by high-speed stirring to obtain a uniform water-in-oil system, which prolongs the action time of the drug and has a slow-release effect; the copper is coated to increase the surface area of ​​the drug , the chance of drug molecule crystallization is reduced, and the stability of the drug is increased; at the same time, the present invention has simple production process, accurate dosage, easy operation, and can complete the production of the emulsion in one step.

Description

technical field [0001] The invention relates to the field of veterinary drugs, in particular to a slow-release injection emulsion for treating bovine copper deficiency and a preparation method thereof. Background technique [0002] With the rapid development of my country's animal husbandry, the production structure of poultry and livestock has gradually changed. While the intensive breeding of chickens and pigs has developed rapidly, the cattle industry has also flourished. However, due to the influence of traditional feeding methods, the research on ruminant nutrition in my country is far behind developed countries in the world. There are few basic researches, and there are even fewer studies on the laws of mineral nutrition and metabolism. The lack or imbalance of trace elements has become a factor restricting the production level of beef cattle in my country. Key factor. Trace elements are necessary for the basic life activities of animals. Although the requirement is ve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/30A61K31/592A61K9/107A61P3/02A61K31/59A61K31/375A61K31/355A61K31/451
Inventor 张艳雯钟诚郑一民
Owner NANNING UNIV
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