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Rare cell filter and application thereof

A rare cell and filter technology, applied in the field of cell filter, can solve the problems of poor selectivity and sensitivity, and achieve the effect of convenient application and high efficiency

Active Publication Date: 2014-06-25
GUANGZHOU ANFANG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to provide a rare cell filter and its application. The present invention solves the problem of poor selectivity and sensitivity in the rare cell capture process, and can achieve efficient and reliable rare cell capture in a short time and detection, while the manufacturing process of the screening membrane is simple, the application is convenient, reliable, and efficient

Method used

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  • Rare cell filter and application thereof
  • Rare cell filter and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Such as figure 1 , image 3 with Figure 5 As shown: a rare cell filter, which includes a filter tube 1 with an opening at one end. The opening of the filter tube 1 extends outward at an angle of 30°, and a beveled reinforcement ring 8 is provided on its outer wall. The filter tube 1 is provided with an elastic sealing head 11 that slides along the inner wall of the filter tube 1. The filter tube 1 and the elastic sealing head 11 form a closed cavity 3 that can accommodate liquid. The injection barrel 2 includes a barrel 2.1 with two ends open, and the barrel 2.1 is connected to the barrel cover 2.4 through threads. The bobbin 2.1 is provided with a reinforcement ring 10 on the upper outer wall

[0066] The other end of the bobbin 2.1 is also provided with a connecting pipe 2.11. The other end of the connecting pipe 2.11 is provided with an annular card edge 2.12. The elastic sealing head 11 is provided with a groove 11.1. The card edge 2.12 is located in the groove...

Embodiment 2

[0081] Such as figure 2 , image 3 with Figure 5 As shown, this embodiment is basically the same as the rare cell filter of embodiment 1, the difference is:

[0082] The inner wall of the cover top of the cylinder cover 2.4 is provided with a circular boss 2.43 smaller than the diameter of the cover top, and the circular boss 2.43 forms an annular groove 2.44 with the cylinder wall of the cylinder cover 2.4, and a sealing gasket 9 is arranged in the annular groove 2.44 , the circular boss 2.43 is provided with a hollow cylinder 2.45 smaller than the diameter of the boss and has multiple lateral gaps, the microporous array filter membrane 2.3 is arranged on the inner wall of the hollow cylinder 2.45, between the microporous array filter membrane 2.3 and the filter support ring A sealing gasket 9 is provided.

Embodiment 3

[0084] Such as figure 1 , image 3 , Figure 4 with Figure 5 Shown: this embodiment is basically the same as the rare cell filter of embodiment 1, the difference is:

[0085] A cylindrical additional inlet 2.41 is arranged in the center of the cylinder cover 2.4, and an additional inlet cover 2.42 is provided on the additional inlet 2.41.

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Abstract

The invention discloses a rare cell filter and application thereof. The filter comprises a filter pipe, wherein an opening is formed at one end of the filter pipe; an elastic sealing head sliding along the inner wall of the filter pipe is arranged inside the filter pipe; a syringe sliding along the inner wall of the filter pipe is arranged above the elastic sealing head in a matching manner; the syringe comprises a bobbin with openings at two ends; a barrel cover is arranged above one end of the bobbin; a filter support ring is arranged at the opening of the bobbin below the barrel cover; a micro-hole array filter membrane with covered opening is arranged on the filter support ring; the bobbin, the elastic sealing head and the filter support ring form a recovery pool; the filter membrane is formed by a conical micro-hole and dual layers of micro-hole arrays with different calibers; a sample tube is arranged inside the recovery pool; one end of the sample tube passes through the filter support ring and extends into a filter cavity; the other end of the sample tube passes through the elastic sealing head and extends into a sealed cavity. By adopting the rare cell filter, the problems of poor selectivity and sensitivity for capturing rare cells are solved, and the rare cell filter is applicable to efficient capture, cultivation and analysis of circulating tumor cells and fetal circulation cells in human peripheral blood.

Description

technical field [0001] The invention relates to a cell filter, in particular to a cell filter suitable for the capture of circulating tumor cells and fetal circulating cells in human peripheral blood and related in vitro early diagnosis, auxiliary diagnosis, individualized treatment, chemotherapy drug evaluation, tumor Cell filters for recurrence monitoring and drug development. Background technique [0002] Cancer is the number one enemy of human health and the most common cause of death. Although there have been a lot of research and practice on the diagnosis and treatment of cancer, and many effective technologies and methods have been developed, these technologies and methods still have a lot of shortcomings in the two aspects of diagnosis and treatment. For example, we still can't do a good early diagnosis and evaluation of chemotherapy. Currently commonly used imaging techniques, including ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI) an...

Claims

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Application Information

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IPC IPC(8): C12M1/24C12M1/12G01N33/574C12N5/09
CPCC12M33/14C12N5/0693
Inventor 陈勇唐亚东石剑汪莉
Owner GUANGZHOU ANFANG BIOTECH CO LTD
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