Anti-fatigue extract, raw material composition thereof, preparation method and applications of anti-fatigue extract

A raw material composition and extract technology, applied in the directions of drug combination, plant raw material, antidote, etc., can solve the problems of lack of drugs, unsatisfactory effect, etc., to improve glycogen reserve, improve anaerobic and aerobic metabolism, Good anti-fatigue effect

Inactive Publication Date: 2014-07-02
SHANGHAI INST OF PHARMA IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide an anti-fatigue extract, its raw material composition, preparation method and application thereof in order to overcome the defects of lack of drugs and unsatisfactory effects in the treatment of fatigue syndrome in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Extraction of medicinal plants

[0032] About 40% by weight of ginseng; about 25% by weight of Epimedium; about 10% by weight of Acanthopanax senticosus by weight; about 10% by weight of Chinese chive seeds; about 10% by weight of Angelica dahurica; about 5% by weight of Hovenia dulcis. Add 6 to 10 times the volume of water, soak for 1 hour, extract twice, decoct at 80°C for 0.5 to 2.5 hours each time, and concentrate to a relative density of 1.2 (the temperature when testing relative density is 60°C) or higher. . Vacuum dried to get dry extract, crushed through 80 mesh sieve.

Embodiment 2

[0033] Example 2 Biological Evaluation

[0034] In the following biological experiments, the effects of anti-fatigue extracts on mice anti-fatigue are mainly investigated

[0035] (1) Experimental animals: ICR male mice, weighing 20-22g, 8-9 weeks old, are caged and monocultured, and are randomly divided into experimental group and control group.

[0036] (2) Experimental methods

[0037] (1) Feeding method of animals: The experimental group was fed with 40mg / kg each day, and the control group was fed with the same volume of water for 14 consecutive days. On the 15th day of the experiment, various indicators were measured.

[0038] (2) Determination of liver glycogen content: The liver was taken immediately after the mice were killed by decapitation and the liver glycogen content was determined by anthrone colorimetry.

[0039] (3) Determination of muscle glycogen content: Take the muscles of both hind limbs to determine the muscle glycogen content by anthrone colorimetry.

[0040] (4) De...

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PUM

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Abstract

The invention discloses an anti-fatigue extract, a raw material composition thereof, a preparation method and applications of the anti-fatigue extract. The raw material composition of the anti-fatigue extract comprises the following components in percentage by weight: 3% to 80% of ginseng, 3% to 80% of epimedium, 3% to 80% of acanthopanax, 3% to 80% of Chinese chive seed, 3% to 80% of dahurian angelica root, and 3% to 80% of hovenia dulcis thunb. The preparation method of the anti-fatigue extract comprises the following steps: adding a solvent into the raw material composition of the anti-fatigue extract; soaking the composition for a while; then decocting, extracting, and condensing so as to obtain extract, and finally drying the extract so as to obtain the anti-fatigue extract. The formula of the anti-fatigue extract is reasonable. It has been proved by pharmacological experiments and clinical cases that the anti-fatigue extract actually has an anti-fatigue effect. Moreover, the anti-fatigue extract can improve the glycogen reserve in human boy, improves the anaerobic metabolism performance and aerobic metabolism performance of human boy, and strengthens the tolerance ability when human body is under a large burden.

Description

Technical field [0001] The invention relates to an anti-fatigue extract, its raw material composition, preparation method and application. Background technique [0002] Chronic Fatigue Syndrome (CFS) is a group of systemic syndromes with long-term extreme fatigue (including physical fatigue and mental fatigue) as the main manifestation, accompanied by headache, sore throat, muscle and joint pain, mental fatigue, and depression , Insomnia, forgetfulness, slow thinking and lack of concentration and other symptoms. It was officially named by the US Centers for Disease Control in 1988, and my country’s ninth edition of "Practical Internal Medicine" was also officially named and identified as a disease. Its basic characteristics are extreme fatigue for a long time, no relief after rest, and generally no abnormal findings in physical examination and routine laboratory examinations. [0003] Chronic fatigue syndrome is divided into several focuses: mainly physical fatigue, mental and ps...

Claims

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Application Information

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IPC IPC(8): A61K36/8962A61P39/00
Inventor 叶庆华昌军
Owner SHANGHAI INST OF PHARMA IND
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