Method for detecting Szechuan lovage rhizome

A detection method, the technology of Chuanxiong, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of poor specificity, difficult to distinguish, unsuitable index components, etc., and achieve the effect of quality assurance

Inactive Publication Date: 2014-08-06
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
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  • Claims
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Problems solved by technology

The content of ligustilide in the crude drug is about 0.6%, accounting for about 58% of the total volatile oil. The content of this component is of certain significance for distinguishing whether it is from the authentic area, but ligustilide can undergo dehydrogenation and oxidation at room temperature , hydrolysis, degradation and other isomerization reactions, the content of medicinal materials changes greatly during storage, and its stability is a concern when it is used as a quality control index; the content of ferulic acid in crude drugs is about 0.1% to 0.2%, However, ferulic acid is a common component of many medicinal plants, and its specificity is poor as a quantitative indicator; while the content of ligustrazine in crude drugs is less than 1 / 10,000, it is not suitable as an index component for quality control of medicinal materials
[0004] In the currently commercially available medicinal materials of Chuanxiong, due to improper processing and preservation, there are a large number of inferior products of Chuanxiong such as moth-eaten and scorched, and there are also phenomena in the market where Ligusticum edulis is mixed with Ligusticum chuanxiong. There are components such as artebenolactone, which are difficult to distinguish

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  • Method for detecting Szechuan lovage rhizome
  • Method for detecting Szechuan lovage rhizome
  • Method for detecting Szechuan lovage rhizome

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Embodiment 1

[0040] Embodiment 1 Detection method of the present invention

[0041] (1) Take about 1.0g of the fine powder of each Rhizoma Chuanxiong sample, weigh it accurately, put it into a stoppered conical flask, add 20ml of ethanol precisely, seal it tightly, and ultrasonically treat it for 40min, filter it, concentrate the filtrate to a 5ml volumetric flask, that is have to.

[0042] (2) Precisely measure 20 μL of the test solution, inject it into a high-performance liquid chromatograph, and detect it at 280 nm. The chromatographic conditions are as follows:

[0043]

[0044] Under the above detection method, multiple common peaks can be separated, and the separation degree of each peak is good, which provides convenience for determining the content of each index component and comparing the similarity of fingerprints. Using the above method to detect medicinal materials of different varieties or textures can not only effectively distinguish the similar varieties of Rhizoma Chuan...

Embodiment 2

[0045] Embodiment 2 The investigation of fingerprint spectrum detection method of the present invention

[0046] ① The preparation method of the test solution was investigated using ethanol as the extraction solvent, and the influence of ultrasonic extraction for 30 minutes and reflux extraction (extracting twice, the first time for 1.5 hours, and the second time for 1 hour) on the chromatographic peak area was investigated. The results showed that ultrasonic extraction Compared with extraction and reflux extraction, the chromatograms are not much different, so the simpler ultrasonic extraction method is chosen. On this basis, the effects of ethanol and methanol on the chromatographic peaks were compared, and the results showed that the number of chromatographic peaks in the ethanol extract was significantly more than that in the methanol extract, so the extraction solvent was determined to be ethanol. The above studies determine that the preparation method of the test solutio...

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Abstract

The invention provides a method for detecting Szechuan lovage rhizome by an HPLC (high performance liquid chromatography) fingerprint spectrum as well as a method for evaluating qualified products, worm-eaten products and burnt products of Szechuan lovage rhizome. According to the method for detecting Szechuan lovage rhizome, the quality of Szechuan lovage rhizome can be effectively distinguished, counterfeit products, qualified products, worm-eaten products and burnt products of Szechuan lovage rhizome can be distinguished accurately, and a novel method for guaranteeing the quality of Szechuan lovage rhizome is provided.

Description

technical field [0001] The invention relates to a detection method of Rhizoma Chuanxiong. Background technique [0002] Chuanxiong, formerly known as Xiongxiong. A traditional Chinese medicine plant, commonly used for promoting blood circulation, dispelling wind and relieving pain, mainly cultivated in Sichuan, Yunnan, Guizhou, Guangxi, Hubei and other places. Ligusticum chuanxiong is pungent, warm, fragrant and dry. When walking but not guarding, it can not only dissipate, but go up to reach the top; enter the blood, go down to reach the sea of ​​blood. It has a wide range of functions of promoting blood circulation and removing blood stasis, suitable for stagnation of various diseases; dispelling wind and relieving pain, has very good effects, and can cure head wind, headache, rheumatic arthralgia and other diseases. The ancients said that Chuanxiong is the qi medicine in the blood, and it is almost said that it has the functions of dispersing pungent, relieving depressi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 彭成刘友平陈林陈鸿平
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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