Preparing method of beta-cyclodextrin immobilized cellulose membrane used for tryptophan chiral separation

A technology of chiral separation and cellulose membrane, which is applied in chemical instruments and methods, membrane technology, semipermeable membrane separation, etc., can solve the problems of complex preparation process, simplify the preparation process, save production cost, and avoid loss Effect

Active Publication Date: 2014-08-27
CHINA PHARM UNIV
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Problems solved by technology

Molecularly imprinted membranes have strong specificity. Each molecularly imprinted membrane can only resolve one chiral substance, and the preparation process is complicated.

Method used

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  • Preparing method of beta-cyclodextrin immobilized cellulose membrane used for tryptophan chiral separation
  • Preparing method of beta-cyclodextrin immobilized cellulose membrane used for tryptophan chiral separation
  • Preparing method of beta-cyclodextrin immobilized cellulose membrane used for tryptophan chiral separation

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Embodiment Construction

[0006] The following describes the features of the present invention in combination with implementation cases:

[0007] Firstly, the β-cyclodextrin-immobilized cellulose membrane was prepared by the following steps, and then the separation performance of the membrane was characterized and evaluated.

[0008] The steps of preparing β-cyclodextrin immobilized cellulose membrane are as follows:

[0009] (1) Membrane pretreatment: Put the 0.22μm cellulose filter membrane into 60mL purified water and soak for 1h, pour out the purified water, and reserve the filter membrane for use.

[0010] (2) Oxidation reaction: Put the filter membrane in a beaker, add periodic acid solution (0.25 mM, 5 mL), and place it in a constant temperature oscillator (25° C., 150 r / min) for constant temperature shaking for 2 hours.

[0011] (3) Cross-linking and solid loading reaction: After shaking at a constant temperature for 2 hours, pour out the periodic acid solution in the beaker, rinse with pure water 3 time...

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Abstract

The invention provides a preparing method of a beta-cyclodextrin immobilized cellulose membrane used for tryptophan chiral separation. According to the preparing method, the cellulose membrane is selected to be used as a base membrane material due to the advantages that the molecular structure per se of the cellulose membrane has multiple active hydroxyls capable of being used for modification, in addition, the price is low, and the acquisition is easy. Beta-cyclodextrin is chemically bonded on the cellulose membrane with the bore diameter of 0.22[mu]m, and chiral separation membranes are prepared. Racemic tryptophan is used as a separation object; in addition, separation effects are expressed; after the multilayer filtering, the modified filter membrane almost achieves the complete separation on DL-tryptophan; and a D-tryptophan solution is obtained. The separation performance stability RSD of the chiral membranes in 12h reaches 3.4 percent, and the stability is good. The preparing method can be widely applied to the field of chemical medicine separation.

Description

Technical field [0001] The invention relates to a method for preparing a membrane for chiral resolution of tryptophan, which is synthesized and loaded to prepare a membrane for chiral resolution, which can be widely used in the field of chemical and pharmaceutical separation. technical background [0002] Membrane technology resolution method uses specific separation functional sites contained inside or outside the membrane to resolve mixed-rotation mixtures. The membrane technology separation method has the advantages of low energy consumption, simple operation, large batch processing capacity, easy continuous operation, easy industrial amplification, flexible device design and system application, and in most cases room temperature operation. According to the morphology of the membrane, the separation method of membrane technology is divided into liquid membrane separation and solid membrane separation. Chiral liquid membranes have a common shortcoming that is difficult to over...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/10B01D67/00C07D209/20
Inventor 季一兵郝单单陈建秋
Owner CHINA PHARM UNIV
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