Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of traditional Chinese medicine composition for preparing anti-aspergillus medicine

An anti-Aspergillus and composition technology is applied in the field of preparing medicines for anti-Aspergillus infection, can solve problems such as large usage of Tween 80, and achieve the effects of good safety, single formula and improved bacteriostatic activity

Active Publication Date: 2016-02-24
THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And in many patents of traditional Chinese medicine preparations, Tween 80 is also widely used, such as the use of Tween 80 as an emulsifier in the patent CN101982109A, and the use of Tween 80 as a surfactant in the patents CN102283806A and CN102526010A, but in the above patents, Tween 80 The usage is relatively large, more than 10%

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of traditional Chinese medicine composition for preparing anti-aspergillus medicine
  • A kind of traditional Chinese medicine composition for preparing anti-aspergillus medicine
  • A kind of traditional Chinese medicine composition for preparing anti-aspergillus medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Cinnamaldehyde: 2.5g (50 parts by weight),

[0026] Patchouli ketone: 1.25g (25 parts by weight),

[0027] Tween 80: 0.01 g (0.2 parts by weight).

Embodiment 2

[0029] Cinnamaldehyde: 78g (78 parts by weight),

[0030] Patchouli ketone: 39g (39 parts by weight),

[0031] Tween 80: 0.1 g (0.1 parts by weight).

[0032] Add 0.1g of Tween 80 into 929.7ml of normal saline, then add 78g of cinnamon aldehyde and 39g of patchouli ketone into the normal saline containing Tween 80, quantify to 1000ml, pack 100ml / bottle, and sterilize at 100℃ 30 minutes. Prepared for injection.

Embodiment 3

[0034] Cinnamaldehyde: 46.8g (46.8 parts by weight),

[0035] Patchouli ketone: 23.4g (23.4 parts by weight),

[0036] Tween 80: 0.5 g (0.5 parts by weight).

[0037] Add 0.5g of Tween 80 into 929.7ml of normal saline, then add 46.8g of cinnamic aldehyde and 23.4g of patchouli ketone into the normal saline containing Tween 80 in turn. Sterilize for 30 minutes. Prepared for injection. Dosage: Intravenous drip for adults, once a day, 100ml each time, seven days as a course of treatment, 1-2 courses of treatment.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a traditional Chinese medicine composition for preparing anti-Aspergillus medicaments, which comprises the following components in parts by weight: cinnamaldehyde: 40-80 parts by weight, and patchouli ketone: 20-40 parts by weight. The pharmaceutical composition of the present invention can be used to treat diseases caused by aspergillus infection, such as pulmonary aspergillus infection, aspergillus sepsis including systemic infection of the whole body, including heart, brain, liver, kidney, pancreas and the like. The present invention has screened out patchouli ketone among many components of patchouli oil, and its antibacterial activity is higher, and has good synergistic effect with cinnamic aldehyde, and both are suitable for use after compatibility, and compare cinnamic aldehyde and cinnamaldehyde The antibacterial activity of Huoxiang oil after compatibility has been significantly improved, and the safety is good.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, which can be used for preparing medicines for resisting aspergillus infection. Background technique [0002] Due to the wide application of broad-spectrum antibiotics, glucocorticoids, and immunosuppressants, as well as bone marrow transplantation, solid organ transplantation, and tumor chemotherapy, invasive fungal disease (IFD) is pulmonary aspergillosis, and its main pathogenic bacteria are The morbidity and mortality of Aspergillus fumigatus and Aspergillus flavus have increased significantly in recent years, and the mortality rate is as high as 58-90%. At present, there are few effective drugs for the clinical treatment of IFD, such as amphotericin B, itraconazole, voriconazole, caspofungin, etc. Most of them are imported products, which are expensive and have serious side effects. Played a certain role, but the mortality rate of pulmonary Aspergillus infection remains high, so ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/366A61K47/34A61P31/10A61K31/11
Inventor 王刚生邓洁华
Owner THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com