Vilazodone hydrochloride composition and preparation method thereof

Abstract

The invention relates to a vilazodone hydrochloride composition and a preparation method thereof. The composition includes vilazodone hydrochloride, a microcarrier and pharmaceutically acceptable excipients for an oral solid preparation. The preparation method is as below: mixing and crushing vilazodone hydrochloride and the microcarrier, and evenly mixing the mixture with pharmaceutically acceptable excipients for oral solid preparation. The obtained composition preparation has greatly improved dissolution in vitro, and in vivo bioavailability reaching bioequivalence to VIIBRYD.

Description

technical field

[0001] The invention relates to a pharmaceutical composition containing vilazodone hydrochloride and a preparation method thereof, belonging to the technical field of medicine. Background technique

[0002] With the development of society and the mental and psychological pressure brought by the fast pace, the incidence of depression has increased significantly. Depression includes unipolar depression (i.e. major depression and psychotic depression), adjustment disorder, minor depression, seasonal affective disorder, bipolar disorder, etc. Major depressive disorder is also called major depressive disorder Symptoms include: depressed mood, decreased interest in daily activities, significant weight or appetite loss, insomnia or hypersomnia, restlessness / pacing (psychomotor agitation), fatigue or excessive sleepiness, feelings of guilt or self-deprecation , Suicidal thoughts. After the onset, it will affect the patient's work, sleep, study, diet and recreationa...

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