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A kind of medical composite biomaterial application and preparation method

A technology of composite biological materials and biological materials, applied in the field of composite biological material application and composite biological materials, can solve the problems of unfavorable wound repair and high production cost, achieve good safety and biocompatibility, fast wound healing and repair , the effect of promoting growth

Active Publication Date: 2018-10-30
ZHEJIANG SUNDOC PHARMA SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the existing products, in terms of sterility protection, most of them are isolated from the outside world. Once bacteria invade, it is not conducive to wound repair; some of them are artificially added chemical antibacterial drugs, which have certain side effects and high production costs.

Method used

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  • A kind of medical composite biomaterial application and preparation method
  • A kind of medical composite biomaterial application and preparation method
  • A kind of medical composite biomaterial application and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] see figure 1 , a medical composite biomaterial application, which is composed of a base layer 1, a wound protection layer 2 and two peeling layers 3, the wound protection layer 2 is closely attached to the center of one side of the base layer 1, and the two peeling layers 3 One end is partially overlapped and covered on the wound-protecting layer 2 to protect the wound-protecting layer. The other ends of the two peeling layers 3 are bonded to the two ends of the base layer 1 for easy peeling during use. The base layer 1 and the wound-protecting layer 2. The corrugated non-woven medical air-permeable adhesive tape with a glue-carrying layer on the surface of the attached side, the wound protection layer 2 is a composite biomaterial, the composite material is made of silk fibroin porous biomaterial and chitosan, and the peeling layer 3 is Release paper, such as glassine paper.

Embodiment 2

[0027] Example 2 Preparation method of wound protection layer

[0028] (1) Raw silk degumming: configure 1% soapy water washing solution, which contains NaHCO with a mass concentration of 0.5% 3 , Soak raw silk in it, the weight ratio of silk to solution is 1:25, the soaking temperature is 70°C, the soaking time is 40 minutes, washed with deionized water, the water temperature is 70°C, soaked at constant temperature for 40 minutes, loosen the silk, and air-dry at room temperature, to spare;

[0029] (2) Preparation of silk fibroin porous biological material: The material obtained in step (1) is roughly opened; the speed is 0.20Hz feeding and transmission mode mixed with cotton; the speed is 0.20Hz fine opening; through the vacuum with metering pump Transfer box transfer, the conditions for controlling the vacuum transfer box are: the main cylinder speed is 20Hz, the doffer speed is 20Hz, and the messy speed is 14Hz; double-layer carding, the carding condition is that the cott...

Embodiment 3

[0034] Example 3 Preparation method of wound protection layer

[0035] 1) Raw silk degumming: configure 1% soapy water washing solution, which contains NaHCO with a mass concentration of 0.5% 3 , Soak raw silk in it, the weight ratio of silk to solution is 1:25, the soaking temperature is 90°C, the soaking time is 60 minutes, washed with deionized water, the water temperature is 90°C, soaked at constant temperature for 60 minutes, loosen the silk, and air-dry at room temperature, to spare;

[0036] 2) Preparation of silk fibroin porous biological material: The material obtained in step 1) is roughly opened; the speed is 0.40Hz feeding and transmission mode mixed with cotton; the speed is 0.40Hz fine opening; through the vacuum transfer box with a metering pump Transfer, the conditions for controlling the vacuum transfer box are: the main cylinder speed is 30Hz, the doffer speed is 30Hz, and the messy speed is 19 Hz; double-layer carding, the carding condition is that the cott...

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Abstract

The invention provides a medical composite biomaterial patch which comprises a base body layer, a wound protection layer and two stripping layers, wherein the wound protection layer is closely attached to the central position on one side of the base body layer; one end of each stripping layer covers the wound protection layer in an overlapping manner; the wound protection layer is made of a silk fibroin porous biomaterial prepared by a specific method; and the wound protection layer is prepared by an opening-carding-lapping-spunlace combined method. The wound protection patch provided by the invention is a natural biomaterial wound protection patch product, has high safety, favorable biocompatibility and higher bacteriostasis, and is suitable for various wounds; the wound protection patch can effectively resist bacteria, diminish inflammation, disinfect a wound, stop bleeding and promote the growth of granulation tissue and epithelial cells, and the wound can be healed and restored quickly; and the wound protection patch has good air permeability, is soft for application and provides a beneficial growth environment for a wound surface.

Description

technical field [0001] The invention belongs to the field of medical materials, and relates to a composite biological material application, which is a composite biological material application for wound repair, healing promotion and antibacterial, and its main component is a composite biological material made of silk fibroin and chitosan. Material. It is suitable for antibacterial, anti-inflammatory, hemostasis, promotion of tissue healing and repair of various wounds and wounds after surgery. Background technique [0002] The wound protection products in the existing medical hygiene materials mainly include: medical cotton balls, cotton swabs, bandages, band-aids, first aid kits, absorbent cotton, absorbent gauze, gauze pads, etc., generally there are two types: non-sterile and sterile. [0003] Among them, the medical gauze packaged in a sterile way can be used directly, while the gauze packaged in a non-sterile way must be sterilized by high temperature and high pressure...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/44
Inventor 李大为
Owner ZHEJIANG SUNDOC PHARMA SCI & TECH CO LTD
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