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Method for preparing tulathromycin compound by taking demethylated azithromycin as raw material

A technology of methyl azithromycin and telamycin, which is applied in the field of preparation of telamycin compounds, can solve the problems of complex disease and multiple pathogenic factors, and achieve the effect of broad antibacterial spectrum and strong antibacterial activity

Inactive Publication Date: 2014-12-10
苏赵珍
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since respiratory tract infections are generally multiple infections, with many pathogenic factors and complex conditions, there is currently no effective preventive method.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0010] Step 1: Substitution reaction:

[0011] 58.0kg of demethylazithromycin (I) was added to a 500L reaction tank, 300L of chloroform and 30.7kg of pyridine were added, and the frozen brine was cooled to 0°C. 16.1 kg of acetic anhydride was added within 20 minutes, and the temperature of the reaction solution was maintained at about 0°C during the addition. After stirring for 2 hours, the temperature was raised to room temperature, and the reaction was stirred for 12 hours. 100 L of saturated aqueous sodium bicarbonate solution was added to the reaction solution, and the pH of the reaction solution was adjusted to 8.5 by 2M aqueous NaOH solution. After stirring for 10 minutes, the mixture was left to stand for layers, and the lower organic phase was taken out. The organic phase was washed once with 50 L of water and 50 L of saturated brine, dried by adding 1 kg of anhydrous magnesium sulfate, and filtered to remove magnesium sulfate. The filtrate was concentrated under red...

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PUM

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Abstract

The invention discloses a method for preparing tulathromycin compound by taking demethylated azithromycin as a raw material. The preparation method comprises the following steps: by taking the demethylated azithromycin as a raw material, performing substitution, oxidation, addition, reduction and condensation reactions, thereby obtaining a target compound. The method has the advantages that the compound is high in antibacterial activity and wide in antibacterial spectrum and has ultra-long half-life period, the whole treatment process is finished by single-dose, and the like.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and in particular relates to a method for preparing a teramycin compound by using demethylazithromycin as a raw material. Background technique [0002] Respiratory tract infection is one of the more difficult to control infectious diseases in animal husbandry, which is seriously harmful to animal husbandry production. When the respiratory tract infection is prevalent, it will cause huge economic losses to animal husbandry production. Therefore, how to prevent and treat the respiratory tract infection of livestock such as pigs and cattle is an important research topic for veterinarians and veterinary drug workers. Because respiratory tract infections are generally multiple infections, many pathogenic factors, and complex conditions, there is currently no very effective prevention method. For respiratory tract infections in animals, while seeking biological control and environmental blocking, d...

Claims

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Application Information

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IPC IPC(8): C07H17/00C07H1/00
Inventor 不公告发明人
Owner 苏赵珍
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