Method for preparing tulathromycin compound by taking demethylated azithromycin as raw material
A technology of methyl azithromycin and telamycin, which is applied in the field of preparation of telamycin compounds, can solve the problems of complex disease and multiple pathogenic factors, and achieve the effect of broad antibacterial spectrum and strong antibacterial activity
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[0010] Step 1: Substitution reaction:
[0011] 58.0kg of demethylazithromycin (I) was added to a 500L reaction tank, 300L of chloroform and 30.7kg of pyridine were added, and the frozen brine was cooled to 0°C. 16.1 kg of acetic anhydride was added within 20 minutes, and the temperature of the reaction solution was maintained at about 0°C during the addition. After stirring for 2 hours, the temperature was raised to room temperature, and the reaction was stirred for 12 hours. 100 L of saturated aqueous sodium bicarbonate solution was added to the reaction solution, and the pH of the reaction solution was adjusted to 8.5 by 2M aqueous NaOH solution. After stirring for 10 minutes, the mixture was left to stand for layers, and the lower organic phase was taken out. The organic phase was washed once with 50 L of water and 50 L of saturated brine, dried by adding 1 kg of anhydrous magnesium sulfate, and filtered to remove magnesium sulfate. The filtrate was concentrated under red...
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