Gold nanorod dimer asymmetric modification method with biocompatibility

A biocompatible, gold nanorod technology, applied in the field of material chemistry, to achieve uniform structure, increased efficiency, and good biocompatibility

Active Publication Date: 2015-01-07
JIANGNAN UNIV
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  • Abstract
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Problems solved by technology

However, the gold nanorods prepared by the traditional seed growth method use cetyltrimethylammonium bromide as a stabilizer in the preparation process

Method used

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  • Gold nanorod dimer asymmetric modification method with biocompatibility
  • Gold nanorod dimer asymmetric modification method with biocompatibility

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Embodiment 1

[0031] All glass instruments were soaked in aqua regia for 24h, washed with double distilled water, and dried for later use. The water used in the experiment was 18.2 MΩ Milli-Q ultrapure water.

[0032] (1) Synthesis of gold nanorods:

[0033] ①Synthesis of seed crystals: Take 0.1mL of 4g / L chloroauric acid solution in a clean Erlenmeyer flask and add it into 1mL of 0.2M CTAB while stirring. The color of the solution changes from colorless to yellowish brown. Then add 0.12mL freshly prepared 0.01M sodium borohydride solution and stir rapidly for 2 min. The color of the solution changed from yellowish brown to light brown.

[0034] ②Gold nanorod growth: take 5mL 4g / L chloroauric acid solution and add it to 5mL 0.2M CTAB, and add 4mL ultrapure water. Another 0.125mL of 0.01M silver nitrate solution and 65μL of 0.1M ascorbic acid solution were added to the above mixed system, stirred and reacted at 28.0°C for 2 min, and the solution changed from brown to colorless. Finally, ...

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Abstract

The invention discloses a gold nanorod dimer asymmetric modification method with biocompatibility, and belongs to the technical field of material chemistry. The method comprises the following steps: synthesizing gold nanorods; assembling gold nanorod dimer; modifying the surface of the gold nanorod dimer with ligands; asymmetrically modifying the gold nanorod dimer; representing the gold nanorod dimer in cells and the like. By fully utilizing the surface properties of the gold nanorods, the ligands of different hydrophilic and hydrophobic properties are modified on the surfaces of the gold nanorods assembled into the dimer through different chemical properties of end faces and side faces of the gold nanorods, then polymer only modifies on the side faces according to different hydrophilic and hydrophobic properties of the ligands, and the exposed end faces can be used for modifying cell-penetrating peptide. Thus, the stability of the gold nanorods in the cells can be guaranteed, and the efficiency of the gold nanorods for entering the cells can also be greatly increased. According to the gold nanorod dimer asymmetric modification method with biocompatibility, the gold nanorod dimer with a uniform structure and good biocompatibility is obtained.

Description

technical field [0001] The invention relates to a method for asymmetrically modifying gold nanorod dimers with biocompatibility, and belongs to the technical field of material chemistry. Background technique [0002] With the development of nanotechnology, more and more nanomaterials are used in living organisms to exert their unique photoelectric properties. Among them, gold nanomaterials have been extensively studied and applied for their unique optical properties and good biocompatibility. Gold nanorods are a kind of rod-shaped gold nanoparticles, which have two plasmonic absorption peaks on the end face and the side face, and its high photothermal conversion efficiency makes it an excellent treatment method in the field of biomedicine. However, the gold nanorods prepared by the traditional seed growth method use hexadecyltrimethylammonium bromide as a stabilizer in the preparation process. This high polymer itself has certain toxicity to organisms, and the gold nanorod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F1/00B22F9/24B82Y40/00
Inventor 徐丽广胥传来孙茂忠匡华马伟刘丽强宋珊珊吴晓玲
Owner JIANGNAN UNIV
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