ERBB3 mutations in cancer
A cancer, cancer detection technology, applied in the determination/inspection of microorganisms, medical preparations containing active ingredients, biochemical equipment and methods, etc., can solve problems such as functional significance that has not yet been studied
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[0275] Example - Oncogenic ERBB3 Mutations in Human Cancers
[0276] Given the importance of ERBB3 in human cancers, we systematically surveyed human cancers and identified recurrent somatic mutations, but also showed that these mutations are transforming. Additionally, we evaluated targeted therapies in ERBB3 mutant-driven animal cancer models and showed that most of them effectively blocked ERBB3 mutant-driven carcinogenesis.
[0277] Materials and methods
[0278] Tumor DNA, mutations and genome amplification
[0279] Appropriately licensed primary human tumor samples were obtained from commercial sources (Figure 1). The human tissue samples used in the studies were de-identified (dual coded) prior to their use and therefore the studies using these samples were not considered human subjects studies under the US Department of Health and Human Services regulations and related guidance (45CFR part 46). Tumor content >70% in all tumors used was confirmed by pathological ...
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