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ERBB3 mutation in cancer

A technology for cancer detection and gastrointestinal cancer, applied in the field of ERBB3 mutations in cancer, can solve problems such as unstudied functional significance

Inactive Publication Date: 2017-03-15
F HOFFMANN LA ROCHE & CO AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although ERBB3 amplification and / or overexpression in some cancers is known, only sporadic occurrences of ERBB3 somatic mutations have been reported, although the functional significance of these mutations has not been investigated

Method used

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  • ERBB3 mutation in cancer
  • ERBB3 mutation in cancer
  • ERBB3 mutation in cancer

Examples

Experimental program
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Effect test

Embodiment

[0280] Example - Oncogenic ERBB3 Mutations in Human Cancers

[0281] Given the importance of ERBB3 in human cancers, we systematically surveyed human cancers and identified recurrent somatic mutations, but also showed that these mutations are transforming. Additionally, we evaluated targeted therapies in ERBB3 mutant-driven animal cancer models and showed that most of them effectively blocked ERBB3 mutant-driven carcinogenesis.

[0282] Materials and methods

[0283] Tumor DNA, mutations and genome amplification

[0284] Properly consented primary human tumor samples were obtained from commercial sources ( figure 1 ). Human tissue samples used in the studies were de-identified (dual coded) prior to their use and therefore studies using these samples were not considered human subjects studies under the US Department of Health and Human Services regulations and related guidance (45CFR Part 46). Tumor content >70% in all tumors used was confirmed by pathological examinat...

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Abstract

The present invention relates to somatic ErbB3 mutations in cancers, including methods for the identification, diagnosis and prognosis of ErbB3 cancers, and methods for the treatment of cancers, including certain subpopulations of patients.

Description

[0001] related application [0002] This application claims priority and benefit under 35 U.S.C. §119(e) of US Provisional Application Serial No. 61 / 629,951 filed November 30, 2011, which is hereby incorporated by reference in its entirety. [0003] field of invention [0004] The present invention relates to somatic ErbB3 mutations in cancers, including methods for the identification, diagnosis and prognosis of ErbB3 cancers, and methods for the treatment of cancers, including certain subpopulations of patients. [0005] Background of the invention [0006] The human epidermal growth factor receptor (HER) family of receptor tyrosine kinases (RTKs) (also known as ERBB receptors) consists of four members: EGFR / ERBB1 / HER1, ERBB2 / HER2, ERBB3 / HER3 and ERBB4 / HER4 (Hynes et al. Nature Reviews Cancer 5, 341-354 (2005); Baselga et al. Nature Reviews Cancer 9, 463-475 (2009)). ERBB family members contain an extracellular domain (ECD), a single-span transmembrane region, an intracellu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/68
CPCC12Q1/6886C12Q2600/156C12Q2600/112A61P35/00C12Q1/6813C12Q1/686A61K31/517A61K39/39558
Inventor B.S.杰斯瓦尔S.塞沙吉里
Owner F HOFFMANN LA ROCHE & CO AG
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