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Quantum dot marking test strip and method for synchronously and quantitatively detecting multiple indices of cardiac markers

A kind of myocardial marker, quantum dot technology, applied in measurement devices, instruments, scientific instruments, etc.

Inactive Publication Date: 2015-01-14
CHENGDU LINGYU BIOTECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The invention discloses a QD labeling test strip and a method for synchronously quantifying multiple indicators of myocardial markers to solve the problem of synchronous and rapid quantification of multiple indicators of myocardial markers in blood samples

Method used

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  • Quantum dot marking test strip and method for synchronously and quantitatively detecting multiple indices of cardiac markers
  • Quantum dot marking test strip and method for synchronously and quantitatively detecting multiple indices of cardiac markers
  • Quantum dot marking test strip and method for synchronously and quantitatively detecting multiple indices of cardiac markers

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Embodiment

[0042] Example: Quantum dot labeled test strips for simultaneous quantification of myocardial markers with multiple indicators are used for simultaneous quantitative detection of blood myocardial markers cTnI, CK-MB, Myo

[0043] 1. Test strip structure

[0044] combine figure 1 be explained. figure 1Among them, the multi-indicator quantum dot marking test strip for synchronously quantifying myocardial markers includes a sample pad 1, a red blood cell filter membrane 2, a marker pad 3, an analysis membrane 7, and a water-absorbing pad fixed on the substrate 8 in sequence. Pad 6.

[0045] The marking pad 3 of the test strip is a glass fiber membrane. The analysis membrane 7 is a nitrocellulose membrane, a nylon membrane, or a nitrocellulose / acetate mixed membrane, on which there are a detection zone (ie T zone) 4 and a quality control zone (ie C zone) 5 . Described backing 8 is polyester or plastic plate.

[0046] In this example, the double-antibody sandwich method wa...

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Abstract

The invention belongs to the field of in-vitro diagnosis and particularly relates to a quantum dot marking test strip and method for synchronously and quantitatively detecting multiple indices of cardiac markers. A marking pad (3) of the test strip is coated by a mixture of all cardiac marker antibodies correspondingly marked by quantum dots with different wavelengths; a zone T (4) of an analysis membrane (7) is coated by a mixture of all cardiac marker antibodies; and a zone C (5) of the analysis membrane (7) is coated by a second antibody. The standard curve of each detected matter is stored by using an electronic tag and is mounted on the test strip. According to the test strip, the standard curve data stored by the electronic tag is read by a detector with a signal detection function, and the concentrations of all the cardiac markers in a sample are synchronously and quantitatively detected by combining fluorescence intensity corresponding to a to-be-detected sample detected by the detector.

Description

technical field [0001] The invention belongs to the field of in vitro diagnosis, and in particular relates to a quantum dot labeling test strip for synchronously quantifying multiple indicators of myocardial markers and a method thereof. Background technique [0002] Acute myocardial infarction is a very dangerous heart disease, and the condition changes rapidly. In my country, more than 1 million people are killed by acute myocardial infarction every year. The detection of myocardial markers is the key to the diagnosis and treatment of cardiovascular diseases. It can not only reduce the mortality rate, but also play a vital role in future rehabilitation. [0003] At present, the serum detection of myocardial markers mainly adopts the serum ELISA method. This method requires a centrifuge to separate the serum first, and medical equipment such as an incubator and a microplate reader. The operation process is complicated, and only one indicator can be detected at a time. Eff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/558G01N33/533
CPCG01N33/558G01N33/533
Inventor 王春英马义才侯飞
Owner CHENGDU LINGYU BIOTECH
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