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Application of N-(4-chloro-2,5-dimethoxyphenyl)-5-isopropyl-2-methoxybenzenesulfonamide in promotion of hair growth

A technology of methoxybenzenesulfonamide and dimethoxyphenyl, which is applied in the field of life medicine, can solve the problems of unsatisfactory effect of pure Chinese herbal medicine preparation, unclear mechanism of action, impossible to apply to patients, etc. Significance and economic value, fast onset, significant application effect

Active Publication Date: 2015-01-28
EAST CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although there are many drugs for the prevention and treatment of hair loss sold on the market, including some hair growth agents known as Chinese herbal preparations, the effect of pure Chinese herbal preparations is not very satisfactory.
The compound monomer used to promote hair growth is mainly minoxidil approved by FDA. Potentially suitable for all patients
Other compound monomers for the treatment of androgenetic alopecia include anti-androgen drug RU58841, finasteride, oral estrogen drugs and tretinoin, but these drugs either have high relapse or low efficiency

Method used

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  • Application of N-(4-chloro-2,5-dimethoxyphenyl)-5-isopropyl-2-methoxybenzenesulfonamide in promotion of hair growth
  • Application of N-(4-chloro-2,5-dimethoxyphenyl)-5-isopropyl-2-methoxybenzenesulfonamide in promotion of hair growth
  • Application of N-(4-chloro-2,5-dimethoxyphenyl)-5-isopropyl-2-methoxybenzenesulfonamide in promotion of hair growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] In this experiment, the C57BL / 6 strain of mice was used as the experimental object to study the compound nitrogen-(4-chloro-2,5-dimethoxyphenyl)-5-isopropyl-2-methoxybenzenesulfonamide (ie , the compound of formula (I)) promotes the hair telogen phase to the growth phase in mice.

[0036] Female mice born in the same littermate were selected to shave their backs with an electric shaver in the early telogen phase (42 days after birth, P42-day-old mice were used here). They were then divided into three groups with 3 mice in each group. (1) Negative control group: 0.1 g of blank base cream was applied on the back of each mouse every day. (2) Positive control group: smear 100 μl of commercially available minoxidil tincture (Mandi, minoxidil content 5%) on the back of each mouse every day; (3) Experimental group: each mouse back every day Apply 0.1 g of the test drug. The hair growth condition on the back of the mice was recorded and photographed regularly. The change si...

Embodiment 2

[0041] Female C57BL / 6 mice born in the same littermate were selected as the experimental subjects in the resting period of hair (this time, 55 days after birth, P55-day-old mice were used), and the back was shaved with an electric shaver. They were then divided into three groups with 3 mice in each group. Negative control group: 0.1 g of blank base cream per day; Positive control group: 100 μl of minoxidil tincture per day; Experimental group: 0.1 g of test drug per day. The formula of the blank basic cream and the formula of the test agent are the same as in Example 1.

[0042] After 14 days of drug application, the hair growth status of mice in each group was as follows: figure 2 As shown, wherein, the coat of the mice in the experimental group has all grown completely; the coat of the mice in the positive control group is still growing, not complete; and the coat of the mice in the negative control group has not yet begun to grow. It can be seen that the hair growth prom...

Embodiment 3

[0049] In this experiment, 50-day-old female mice born in the same littermate of the C57BL / 6 strain were selected, and their backs were shaved with an electric shaver. They were then divided into three groups with 3 mice in each group. (1) Negative control group: 100 μl of blank basic water was applied on the back of each mouse every day. (2) Positive control group: smear 100 μl of commercially available minoxidil tincture (Mandi, minoxidil content 5%) on the back of each mouse every day; (3) Experimental group: each mouse back every day Apply 100 μl of test solution. The hair growth condition on the back of the mice was recorded and photographed regularly. Refer to Example 1 and Example 2 for other experimental steps and processes, etc.

[0050] Wherein, the formula of the blank basic water solution contains: 50 milliliters of ethanol, 20 milliliters of 1,2-propanediol, 5 milliliters of dimethyl sulfoxide, and 25 milliliters of water per 100 milliliters.

[0051] Wherein,...

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Abstract

The invention discloses an application of N-(4-chloro-2,5-dimethoxyphenyl)-5-isopropyl-2-methoxybenzenesulfonamide in preparation of composition for promoting hair growth. The N-(4-chloro-2,5-dimethoxyphenyl)-5-isopropyl-2-methoxybenzenesulfonamide is capable of promoting hair follicles to transform from a resting stage to a growing stage, has effects of starting and remarkably promoting hair growth, is quick in response and remarkable in effect, can be used for preparing medicines or cosmetics for treating alopecia or promoting hair growth, and has wide application prospect and value.

Description

technical field [0001] The invention relates to the technical field of life medicine, in particular to a hair promoter (nitrogen-(4-chloro-2,5-dimethoxyphenyl)-5-isopropyl-2-methoxybenzenesulfonamide) Composition thereof, and application thereof in promoting hair growth. Background technique [0002] Hair loss is a problem for many people today. There are many reasons for pathological hair loss. At present, the most important clinical ones include: congenital genetic defects, hair loss caused by chemotherapy, hair loss caused by mental stress, and androgen-derived Alopecia (AGA), also known as male pattern baldness, also occurs in women. [0003] Although there are many medicines for preventing and treating alopecia sold in the market, including some hair growth agents known as Chinese herbal medicine preparations, the pure Chinese herbal medicine preparation effect is not very satisfactory. The compound monomer used to promote hair growth is mainly minoxidil approved by F...

Claims

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Application Information

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IPC IPC(8): A61K8/46A61K31/18A61P17/14A61Q7/00
Inventor 叶希韵任小林张叶刘连喜
Owner EAST CHINA NORMAL UNIVERSITY
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