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Scorpion ferment and ultra-filtrated object, and preparation procedure and usage thereof

A fermented product and whole scorpion technology, applied in traditional Chinese medicine fermented product and its application fields, can solve the problems of high mortality, large side effects of chemotherapy, poor recovery and the like, and achieve the effects of simple and reasonable preparation process and remarkable effect.

Inactive Publication Date: 2015-01-28
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Cancer is the second largest killer next to cardiovascular and cerebrovascular diseases in the world today, especially lung cancer, which has a high incidence rate, poor prognosis, and high mortality. It is currently the most dangerous disease. Currently, Western medicine mainly uses Chemotherapy, but the side effects of chemotherapy are large, which brings great pain to patients, and the treatment effect is not ideal

Method used

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  • Scorpion ferment and ultra-filtrated object, and preparation procedure and usage thereof
  • Scorpion ferment and ultra-filtrated object, and preparation procedure and usage thereof
  • Scorpion ferment and ultra-filtrated object, and preparation procedure and usage thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Adopt the following method to prepare a kind of scorpion fermentation product:

[0030] (1) Rinse the live wild East Asian scorpion with clean water, drain, and then put it in a freezer at -18°C for 72 hours, homogenize it, and freeze-dry it at a cold trap temperature of -60°C, vacuum degree of 1Pa, and room temperature 12 hours to powder to obtain scorpion freeze-dried powder;

[0031] (2) Take 25 parts by weight of scorpion freeze-dried powder, add 2 parts by weight of live Beauveria bassiana spore powder (10 billion / g, produced by Shandong Academy of Agricultural Sciences), add 10 parts by weight of water, mix well, and place at a constant temperature In a wet incubator at a temperature of 25°C and a humidity of 70%, ferment for 8 days to obtain a scorpion fermented product.

[0032] (3) Take the scorpion fermented product, add 25 times its weight in pure water, ultrasonically extract twice, 30 minutes each time, combine the extracts, and filter to obtain the scorpi...

Embodiment 2

[0038] Rinse the live wild East Asian scorpion with clean water, drain, and then put it into a freezer at -60°C for 2 hours, homogenize it, and freeze-dry it for 24 hours to Powdered scorpion freeze-dried powder;

[0039] Get 25 parts by weight of the scorpion freeze-dried powder obtained above, add 12 parts by weight of live Beauveria bassiana spore powder (10 billion / g, made by Shandong Academy of Agricultural Sciences), add 15 parts by weight of pure water, mix well, and place Ferment in a constant temperature and humidity incubator at a temperature of 26°C and a humidity of 80% for 20 days to obtain a scorpion fermented product.

[0040] Take the scorpion fermented product, add 30 times its weight in pure water, ultrasonically extract 3 times, each time for 45 minutes, and combine the extracts to obtain the scorpion fermented product. Ultrafiltration was carried out with 30KDa and 3 KDa ultrafiltration membranes, respectively, to obtain ultrafiltrates with relative molecu...

Embodiment 3

[0046] Rinse the live wild East Asian scorpion with clean water, drain, and then freeze in a freezer at -30°C for 48 hours, homogenate, freeze-dry for 18 hours to Powdered scorpion freeze-dried powder;

[0047] Get 25 parts by weight of the scorpion freeze-dried powder obtained above, add 25 parts by weight of live Beauveria bassiana spore powder (10 billion / g produced by Shandong Academy of Agricultural Sciences), add 25 parts by weight of purified water, mix well, and place In a constant temperature and humidity incubator at a temperature of 28°C and a humidity of 95%, ferment for 30 days to obtain a scorpion fermented product.

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Abstract

The invention discloses a scorpion ferment and ultra-filtrated object, and the preparation processes and usage thereof. A freeze drying ferment process is adopted for preparing a scorpion ferment, and then through the ultra-filtration of different filter membranes of an ultra-filter, the scorpion ultra-filtrated object with different and relative molecular masses can be obtained. The preparation process provided by the invention is simple, the prepared scorpion ferment and the prepared scorpion ultra-filtrated object can restraint the growth of viruses and cancer cells, and particularly have remarkable effects in resisting activities of viruses of HSV1, H1N1 and RSV and restraining the growth of tumor cells of lung adenocarcinoma (A549).

Description

technical field [0001] The invention relates to a scorpion fermented product and an ultrafiltered product, a preparation process and its application in inhibiting the growth of viruses and cancer cells, and belongs to the technical field of traditional Chinese medicine fermented products and their application. Background technique [0002] Virus infection is currently the most frequent, most widespread, and most harmful type of disease in the world. Every year, countries around the world invest a lot of manpower and material resources in the development and research of antiviral drugs. Due to the variability of the virus itself, this determines the difficulty of developing antiviral drugs. Nevertheless, people are still persistently studying new technologies and methods to fight against various viruses. At present, the number of antiviral drugs is limited, and the effect is not satisfactory. There are still no effective solutions for some viruses. Fermented product of scorp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/646A61P35/00A61P31/12A61P31/22A61P31/16A61P31/14
CPCA61K35/646A61K9/19
Inventor 王集会王俊香高世杰焦方文马明珠
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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