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Combination Drugs Used to Treat Dementia or Cognitive Impairment

A technology for cognitive dysfunction and dementia, which can be used in drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients. The effect of object recognition ability

Active Publication Date: 2019-01-08
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, although a single drug molecule targeting multiple targets can reduce adverse reactions and clinical doses in theory, its research and development costs are high and the clinical efficacy cannot be guaranteed; while compound preparations are based on combination drugs, which are essentially the same. Therefore, screening and evaluating effective combination drugs is an important way to prevent and treat dementia or cognitive dysfunction
[0012] At present, the combination of non-steroidal anti-inflammatory drugs and statins for the treatment of senile dementia has not been reported

Method used

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  • Combination Drugs Used to Treat Dementia or Cognitive Impairment
  • Combination Drugs Used to Treat Dementia or Cognitive Impairment
  • Combination Drugs Used to Treat Dementia or Cognitive Impairment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Embodiment 1. The effect of the combined drug of the present invention on the object recognition and memory ability of rapid aging model mice ring

[0081] 1. Materials

[0082] 1.1 Animals: rapid aging model mouse SAMP8 (clean grade) and anti-rapid aging model mouse SAMR1 (clean grade), weighing 29-33 g.

[0083] 1.2 Reagents and drugs: donepezil hydrochloride; memantine hydrochloride; drug prescription A, atorvastatin calcium salt and indomethacin (weight ratio 1:1); drug prescription B, atorvastatin calcium salt and ibuprofen ( Weight ratio 1:25).

[0084] 1.3 Experimental equipment: The size of the custom-made test box is 30×30×30cm (width×length×height), the box body is black opaque plexiglass, and the bottom of the box is transparent plexiglass. The video of mice exploring objects was collected by Anymaze software.

[0085] 2. Method

[0086] 2.1 Administration method

[0087] According to the weight of the mice, the mice were randomly divided into five gr...

Embodiment 2

[0101] Embodiment 2. The influence of the combined drug of the present invention on the passive avoidance response ability of rapid aging model mice ring

[0102] 1. Materials

[0103] 1.1 Animals: Same as Example 1.

[0104] 1.2 Reagents and drugs: donepezil hydrochloride; memantine hydrochloride; prescription A, atorvastatin calcium salt and indomethacin; prescription B, atorvastatin calcium salt and ibuprofen. The details are the same as in Example 1. 1.3 Experimental apparatus: platform device (DTT-2, Chinese Academy of Medical Sciences), the box body is a plastic cuboid with the upper cover open and the two sides opaque, and the size is 22 × 28 × 36cm (width × length × height) , the bottom surface is a stainless steel grid, and the grid spacing is 1.5cm (36v voltage can be passed). The platform is a cuboid plastic foam: 8×8×2.5cm (width×length×height). Place the platform in the center of the box, 7 and 10cm away from both sides of the box.

[0105] 2. Method

[0...

Embodiment 3

[0119] Embodiment 3. The effect of the combination drug of the present invention on the spatial learning and memory ability of rapid aging model mice ring

[0120] 1. Materials

[0121] 1.1 Animals: Same as Example 1.

[0122] 1.2 Reagents and drugs: donepezil hydrochloride; memantine hydrochloride; prescription A, atorvastatin calcium salt and indomethacin; prescription B, atorvastatin calcium salt and ibuprofen. Specifically with embodiment 1.

[0123] 1.3 Experimental equipment: Morris water maze (DNS-2, Chinese Academy of Medical Sciences) includes the following three parts: the experimental device is composed of the maze body (pool), video acquisition system, related graphics processing software and computer: the diameter of the palace body is 100cm, The maze wall was 30cm above the water surface, and the safety platform (circular, 10cm in diameter, with a rough surface for animals to grasp) was hidden under the water surface of 1-2cm, and the water temperature was ...

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Abstract

The invention provides a combination medicament for preventing and treating dementia and / or cognitive impairment. Particularly, the combination medicament comprises a) non-steroidal anti-inflammatory drugs or pharmaceutical salts thereof of effective dose for prevention and / treatment, b) statins compounds or pharmaceutical salts thereof of effective dose for prevention and / treatment, and c) optional pharmaceutically acceptable carrier or excipient. According to the combination medicament, the object cognition capability, passive avoidance response capability, active avoidance response capability and spatial learning and memorizing capability of model mice can be effectively increased and improved, therefore, the combination medicament can be used for preventing or treatment dementia and / or cognitive impairment and other diseases.

Description

technical field [0001] The present invention relates to a combined medicine, in particular to a combined medicine for treating dementia and / or cognitive dysfunction. Background technique [0002] Dementia is a syndrome of brain disorders, usually of a chronic progressive nature, with multiple disturbances of higher cortical function in conscious situations, usually with impairment of cognitive function and occasionally with emotional control and social behavior Or a decline in motivation is a prodrome. Dementia is an acquired and persistent intellectual disability. Intellectual disability refers to at least three obstacles in the following areas of mental activity: ①language, ②memory, ③visual space, ④emotion, ⑤personality, ⑥cognition (abstract thinking, calculation, etc.) , judgment and executive ability, etc.). Therefore, dementia is acquired intellectual dysfunction, rather than congenital mental retardation, and the emphasis is on persistent intellectual disability. Th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61P25/28A61P25/00
Inventor 张永祥周文霞程肖蕊王健辉曾菊徐一冉张小锐刘港程军平
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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